搜索结果: 1-15 共查到“知识库 research”相关记录1957条 . 查询时间(0.171 秒)
Research on the Temporal and Spatial Distributions of Standing Wood Carbon Storage Based on Remote Sensing Images and Local Models
remote sensing GWR MGWR TWR GTWR standing wood carbon storage
2023/12/6
Background and Objectives: It is important to understand the temporal and spatial distributions of standing wood carbon storage in forests to maintain ecological balance and forest dynamics. Such info...
Preparation and research of epoxy modified by carboxyl-terminated polybutylene adipate at room temperature
NANOFILLERS IMPROVEMENT RESIN
2023/12/1
In this study, carboxyl-terminated polybutylene adipate (CTPBA) was used to modify epoxy resin, and the modified epoxy resin was cured by a room temperature rapid curing agent (T-31). The effects of C...
Fluorescent biosensors illuminating plant hormone research
phytohormones fluorescent biosensors FRET biosensors plant growth plant hormone
2023/12/1
Phytohormones act as key regulators of plant growth that coordinate developmental and physiological processes across cells, tissues and organs. As such, their levels and distribution are highly dynami...
Research on Ecological Compensation of National Parks Based on Tourism Concession Mechanism
protected natural areas ecological compensation concession Pilot Programs for Shennongjia National Park System
2023/11/20
The Chinese government has already proposed to build a nature protected area system composed mainly of national parks and encourages the development of concession operations in national parks. The est...
DNA双链断裂(double strand break,DSB)是极为严重的DNA损伤形式。如果不对其进行修复或修复错误及修复不及时,可导致基因组突变和更大范围的结构重排,引起细胞癌变或者基因组不稳定性相关疾病等。
武汉大学药学院邓子新院士团队和芝加哥大学化学系Chuan He教授团队合作,在Cell Research(一区,IF=44.1)发表了题为“Nm-Mut-seq: abase-resolution quantitative method for mapping transcriptome-wide 2′-O-methylation”的研究论文(2023年6月15日上线)。陈黎博士是该论文的第一作者...
Research advances on process systems integration and process safety in China
heat integration process safety management process synthesis water network optimization
2023/6/19
Process systems engineering research focuses on the planning, design, operation, and safety of process systems rather than unit operations. In response to the rapid growth of the chemical process indu...
心血管疾病(Cardiovascular disease,CVD)是全球范围内最主要的死因,动脉粥样硬化(atherosclerosis, AS)是众多心脑血管疾病发生的共同病理基础,流体剪切力(fluid shear stress, FSS)是调控AS发生的重要因素。作为血液和血管组织间屏障的血管内皮细胞(Vascular endothelial cells, VECs)在AS发生发展过程中起着...
近日,中南大学湘雅医院临床药理研究所张伟教授团队的原创性成果“Cancer Nanobombs Delivering Artoxplatin with a Polyigniter Bearing Hydrophobic Ferrocene Units Upregulate PD-L1 Expression and Stimulate Stronger Anticancer Immunity”和“E...
2023年03月27日,上海市免疫学研究所陈磊研究员团队在Genome Research上发表了题为“Simultaneous profiling of host expression and microbial abundance by spatial meta-transcriptome sequencing”的研究论文。该研究首次开发了空间宏转录组测序及一体化的生物信息分析技术SMT(Spa...
猴痘是由猴痘病毒(MPXV)引起的人畜共患病毒性疾病,首例人感染猴痘的病例1970年于刚果发现。2022年5月猴痘病毒在英国爆发,迅速席卷一百多个国家。2022年7月23日,猴痘疫情被世卫组织宣布为突发公共卫生事件。目前全球已有8.5万确诊病例,这给全球的人类健康构成了巨大威胁。因此,迫切需要开展针对猴痘病毒的基础研究,为临床治疗提供重要的理论基础。
基因表达的精准调控,对机体发育和细胞的各种生理功能的维持至关重要。真核生物基因的转录主要分为转录起始(initiation)、暂停-释放(pausing-release)、延伸(elongation)和终止(termination)四个步骤,转录进程的顺利进行与DNA修饰、组蛋白修饰和RNA修饰等表观遗传修饰高度相关【1】。组蛋白修饰(histone modification)是指组蛋白在相关酶催...
肿瘤学顶级期刊《Clinical Cancer Research》(影响因子13.801;17/245,Oncology,Q1)近日在线发表北京航空航天大学医学科学与工程学院,生物医学工程高精尖创新中心于健教授团队、陈伟副教授团队及北京高博博仁医院克晓燕、胡凯主任团队合作的最新研究成果“Single-cell transcriptomics reveals immune reconstitutio...
DNA加合物损伤可以由多种外源因子诱导产生,包括阳光中的紫外线、顺铂等化疗药物、香烟和汽车尾气中的苯并芘以及来自霉变食物的黄曲霉素B1等。它们会干扰DNA复制和转录,诱导突变和细胞死亡,最终导致癌症及其它疾病。
Circulation Research | 周菁课题组与合作者发现基质刚度通过盘状结构域受体1(DDR1)的“液-液”相分离机制抑制Hippo通路(图)
高血压 糖尿病 高脂血症
2023/8/11
动脉硬化在慢性肾病患者中普遍存在,其发生率和严重程度与心血管危险因素密切相关,包括年龄、高血压、糖尿病和高脂血症等。细胞外基质(ECM)刚度可影响血管平滑肌细胞(VSMCs)的表型和行为。ECM硬化会导致VSMC过度增殖、迁移,并从收缩表型向合成表型转化。然而,细胞是如何感知ECM刚度的改变,并将力学信号转化成生物学信号,这一问题仍有待深入研究。