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Measuring Electric Fields and Noncovalent Interactions Using the Vibrational Stark Effect
Organic Chemicals Proteins Vibration Models,Molecular Static Electricity
2016/5/25
Over the past decade, we have developed a spectroscopic approach to measure electric fields inside matter with high spatial (<1 Å) and field (<1 MV/cm) resolution. The approach hinges on exploiti...
Extreme Electric Fields Power Catalysis in the Active Site of Ketosteroid Isomerase
Electric Power Catalysis Active Site Ketosteroid Isomerase
2016/5/25
Enzymes use protein architecture to impose specific electrostatic fields onto their bound substrates, but the magnitude and catalytic effect of these electric fields have proven difficult to quantify ...
Calculations of the Electric Fields in Liquid Solutions
Calculations Electric Fields Liquid Solutions
2016/5/25
The electric field created by a condensed-phase environment is a powerful and convenient descriptor for intermolecular interactions. Not only does it provide a unifying language to compare many differ...
Quantitative,Directional Measurement of Electric Field Heterogeneity Within an Enzyme Active Site
Quantitative Directional Measurement Electric Field Heterogeneity Enzyme Active Site
2016/5/25
Extensive structural studies of enzymes have revealed that biological catalysis occurs within sequestered active site crevices, where reacting substrates are surrounded by an anisotropic and chemicall...
Direct Measurements of Electric Fields in Weak OH••π Hydrogen Bonds
Direct Measurements Electric Fields Weak OH• • π Hydrogen Bonds
2016/5/25
Hydrogen bonds and aromatic interactions are of widespread importance in chemistry, biology, and materials science. Electrostatics play a fundamental role in these interactions, but the magnitude of t...
Phosphate Vibrations Probe Local Electric Fields and Hydration in Biomolecules
Phosphates Water Phospholipids Spectrophotometry, Infrared Electricity Models, Molecular
2016/5/25
The role of electric fields in important biological processes such as binding and catalysis has been studied almost exclusively by computational methods. Experimental measurements of the local electri...
Site-Specific Conversion of Cysteine Thiols into Thiocyanate Creates an IR Probe for Electric Fields in Proteins
food packaging perfluorinated dietary intake human exposure
2016/5/24
The nitrile stretching mode of the thiocyanate moiety is a nearly ideal probe for measuring the local electric field arising from the organized environment of the interior of a protein. Nitriles were ...
Electric Fields at the Active Site of an Enzyme:Direct Comparison of Experiment with Theory
Humans Nitriles Enzyme Inhibitors Spectrophotometry, Infrared Spectrum Analysis Circular Dichroism Electricity Protein Conformation Protein Structure,Tertiary Protein Folding
2016/5/24
The electric fields produced in folded proteins influence nearly every aspect of protein function. We present a vibrational spectroscopy technique that measures changes in electric field at a specific...
Controlling Two-Dimensional Tethered Vesicle Motion Using an Electric Field:Interplay of Electrophoresis and Electro-Osmosis
Electric field effects Electrophoresis Electroosmosis DNA Lipids Dynamic response
2016/5/24
We recently introduced methods to tether phospholipid vesicles or proteoliposomes onto a fluid-supported lipid bilayer using DNA hybridization (Yoshina-Ishii, C.; Miller, G. P.; Kraft, M. L.; Kool, E....
Vibrational Stark Effects Calibrate the Sensitivity of Vibrational Probes for Electric Fields in Proteins
transitional cell carcinoma cDNA microarray molecular markers expression profiling tumor classification
2016/5/24
Infrared spectroscopy is widely used to probe local environments and dynamics in proteins. The introduction of a unique vibration at a specific site of a protein or more complex assembly offers many a...
Origins of the Sensitivity of Molecular Vibrations to Electric Fields:Carbonyl and Nitrosyl Stretches in Model Compounds and Proteins
phosphoenolpyruvate carboxylase thermostable limited proteolysis flexible loop main chain connectivity
2016/5/24
The vibrational Stark effect (VSE) is the effect of an electric field on the vibrational spectrum. Typically, the largest change induced by an electric field is the linear frequency shift whose sensit...
Lateral Reorganization of Fluid Lipid Membranes in Response to the Electric Field Produced by a Buried Charge
Thuja dolabrata var. hondai cell culture beta-thujaplicin hinokitiol semi-continuous culture system
2016/5/23
A thermodynamic model describing multicomponent fluid membranes under the influence of lateral forces due to a buried charge is developed to estimate the magnitude and dynamics of field-induced latera...
Electric Field Effects in Multicomponent Fluid Lipid Membranes
melatonin impurities bulk drug substance analytical methods impurity profile residual solvent stability purity
2016/5/23
A thermodynamic model of multicomponent fluid membranes under the influence of lateral forces is described. Membrane components are characterized by their effective molecular areas, molecular charges,...
Electric Field-Induced Critical Demixing in Lipid Bilayer Membranes
Cardiolipins Electric Stimulation Electricity Fluorescent Dyes Lipid Bilayers Membranes, Artificial Microscopy, Fluorescence Models, Chemical Models, Molecular hosphatidylcholines Phosphatidylethanolamines Thermodynamics
2016/5/23
Electric fields can induce lateral reorganization of lipids in fluid bilayer membranes. The resulting concentration profiles readily are observed in planar-supported bilayers by epifluorescence micros...
Electric Field-Induced Reorganization of Two-Component Supported Bilayer Membranes
Electric Field-Induced Two-Component Bilayer Membranes
2016/5/23
Application of electric fields tangent to the plane of a confined patch of fluid bilayer membrane can create lateral concentration gradients of the lipids. A thermodynamic model of this steady-state b...