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Electronic cigarette aerosols induce oxidative stress-dependent cell death and NF-kappa B mediated acute lung inflammation in mice
Electronic cigarette aerosol Acute lung inflammation Oxidative stress NF-κ b pathway Aldehyde
2023/6/21
Electronic cigarette (e-cigarette) use has been linked to recent acute lung injury case clusters in over 2000 patients and dozens of deaths in the United States, however, the mechanism leading to lung...
Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2
SARS-CoV-2 human ACE2 transgenic mouse COVID-19 pneumonia
2020/6/11
COVID-19 has spread worldwide since 2019 and is now a severe threat to public health. We previously identified the causative agent as a novel SARS-related coronavirus (SARS-CoV-2) that uses human angi...
Exercise Training Reverses Extrapulmonary Impairments in Smoke-exposed Mice
DIAPHRAGM SKELETAL MUSCLE ENDOTHELIUM HIGH-INTENSITY INTERVAL TRAINING MITOCHONDRIAL FUNCTION COPD
2018/4/24
Purpose Cigarette smoking is the main risk factor for chronic obstructive pulmonary disease and emphysema. However, evidence on the extrapulmonary effects of smoke exposure that precede lung impairmen...
Exercise Attenuates High-Fat Diet–induced Disease Progression in 3xTg-AD Mice
INSULIN RESISTANCE EXERCISE TRAINING ALZHEIMER'S DISEASE COGNITIVE DECLINE
2018/4/24
Purpose Little is known regarding the therapeutic role of exercise against the risk of a high-fat diet (HFD) for Alzheimer's disease (AD) and AD-like cognitive deficits. This study aimed to investigat...
Oral administration of heat killed Tsukamurella inchonensis enhances immune responses and intestinal function in mice
immunomodulation delayed type hypersensitivity haemagglutination titre intestine villus histology liver spleen kidney
2016/12/8
We studied the effects of heat-killed Tsukamurella inchonensis on immune parameters and intestinal structure in mice. Mice were treated with three doses of bacteria (5 × 107, 1 × 108 and 2 × 108 CFU/m...
Moderate folic acid supplementation and MTHFD1-synthetase deficiency in mice, a model for the R653Q variant, result in embryonic defects and abnormal placental development
birth defects developmental defects embryo folic acid high folate methylenetetrahydrofolate reductase MTHFD1 placenta
2018/12/19
Background: Moderately high folic acid intake in pregnant women has led to concerns about deleterious effects on the mother and fetus. Common polymorphisms in folate genes, such as methylenetetrahydro...
Ovariectomy increases squamous metaplasia of the uterine horns and survival of SENCAR mice fed a vitamin A–deficient diet
ovariectomy survival vitamin A deficiency
2016/6/1
Retinoic acid is necessary for the growth and differentiation
of organisms and exerts its molecular actions by
binding to specific nuclear receptors that belong to the thyroidsteroid
hormone recept...
Effect of Polysaccharides from Acanthopanax senticosus on Intestinal Mucosal Barrier of Escherichia coli Lipopolysaccharide Challenged Mice
Herbal Extract Intestinal Barrier Inflammation Epidermal Growth Factor Pro-inflammatory Cytokines Metabolism
2016/5/20
To investigate the role of polysaccharide from Acanthopanax senticosus (ASPS) in preventing lipopolysaccharide (LPS)-induced intestinal injury, 18 mice (at 5 wk of age) were assigned to three groups w...
Ultrasonic vocalizations of adult male Foxp2-mutant mice:behavioral contexts of arousal and emotion
Adult mice arousal emotional vocalization Foxp2 mutation positive emotion speech disorder ultrasonic vocalization
2016/5/3
Adult mouse ultrasonic vocalizations (USVs) occur in multiple behavioral and stimulus contexts associated with various levels of arousal, emotion and social interaction. Here, in three experiments of ...
Differential Expression of Genes Important to Efferent Ductules Ion Homeostasis across Postnatal Development in Estrogen Receptor-慣 Knockout and Wildtype Mice
P450 Aromatase Estrogen Epithelial Ion Transporters
2016/4/27
Our earlier studies showed that estrogen was involved in the regulation of fluid reabsorption in adult mouse efferent ductules (ED), through estrogen receptor (ER) ??and ER?? by modulating gene expres...
< Previous Article Next Article > Endurance Training Attenuates Catabolic Signals Induced by TNF- in Muscle of Mice
EXERCISE INFLAMMATION UBIQUITIN-PROTEASOME PATHWAY
2017/4/13
Purpose: To determine whether endurance training attenuates the negative effects induced by an acute injection of tumor necrosis factor-α (TNF-α) in skeletal muscle of mice.
Methods: Trained (6 wk of...
The Effects of Aerobic Exercise on Plasma Adiponectin Level and Adiponectin-related Protein Expression in Myocardial Tissue of ApoE-/- Mice
Aerobic exercise, adiponectin, myocardial tissue
2016/2/23
Numerous reports have confirmed the effect of ApoE knockout
in the induction of cardiovascular diseases and the protective
effect of adiponectin against the progression of cardiovascular
disease...
Expression and Distribution of the Guanine Nucleotide-binding Protein Subunit Alpha-s in Mice Skin Tissues and Its Association with White and Black Coat Colors
Mice Guanine Nucleotide-binding Protein Subunit Alpha-s Coat Color Hair Follicle Skin Tissue Melanocyte
2016/11/10
Guanine nucleotide-binding protein subunit alpha-s (Gnαs) is a small subunit of the G protein-couple signaling pathway, which is involved in the formation of coat color. The expression level and distr...
Neural transcriptome of constitutional Pten dysfunction in mice and its relevance to human idiopathic autism spectrum disorder
constitutional Pten dysfunction mice
2015/12/21
Autism spectrum disorder (ASD) is a neurodevelopmental condition with a clear, but heterogeneous, genetic component. Germline
mutations in the tumor suppressor Pten are a well-established risk factor...
Microcurrent Electrical Neuromuscular Stimulation Facilitates Regeneration of Injured Skeletal Muscle in Mice
Muscle injury regenerative potential
2015/8/28
Conservative therapies, mainly resting care for the damaged
muscle, are generally used as a treatment for skeletal muscle
injuries (such as muscle fragmentation). Several past studies
reported t...