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Folate and homocysteine metabolism and gene polymorphisms in the etiology of Down syndrome
homocysteine metabolism gene polymorphisms
2016/6/1
One of the major advances in preventing malformations in the
past few decades had its origin in the observation by Smithells et
al (1) that multivitamin preparations are protective against neural
t...
Relations of glutamate carboxypeptidase II (GCPII) polymorphisms to folate and homocysteine concentrations and to scores of cognition, anxiety, and depression in a homogeneous Norwegian population: the Hordaland Homocysteine Study
Glutamate carboxypeptidase II GCPII folate homocysteine cognition gene polymorphisms
2008/12/17
Background: Glutamate carboxypeptidase II (GCPII) encodes for intestinal folate hydrolase and brain N-acetylated -linked acidic dipeptidase. Previous studies provided conflicting results on the effect...
The ability of fish oil to suppress tumor necrosis factor α production by peripheral blood mononuclear cells in healthy men is associated with polymorphisms in genes that influence tumor necrosis factor α production
TNF-α production lymphotoxin α genotype fish oil inflammation healthy men peripheral blood mononuclear cells TNF*1 TNF*2 TNFB*1 TNFB*2
2016/12/19
Background: Tumor necrosis factor α (TNF-α) mediates inflammation. High TNF-α production has adverse effects during disease. Polymorphisms in the TNF-α and lymphotoxin α genes influence TNF-α producti...
High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased Km):relevance to genetic disease and polymorphisms
Genetic disease therapeutic vitamin use binding defect favism alcohol intolerance autism migraine headaches single nucleotide polymorphisms enzyme mutations review
2016/12/17
As many as one-third of mutations in a gene result in the corresponding enzyme having an increased Michaelis constant, or Km, (decreased binding affinity) for a coenzyme, resulting in a lower rate of ...
Apolipoprotein B gene polymorphisms and serum lipids: meta-analysis of the role of genetic variation in responsiveness to diet
Apolipoprotein B cholesterol diet meta-analysis, human polymorphism restriction endonuclease restrictionfragment-length polymorphism restriction-site polymorphism, plasma lipids
2016/6/3
Background: The genetic variance determining plasma lipid and
lipoprotein concentrations may modify individual responsiveness
to alterations in dietary fat and cholesterol content.
Objective: The a...