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Over the past decade, the approval of immune checkpoint inhibitors has revolutionized treatment for patients with advanced lung cancer, helping many live longer lives and improving overall survival fo...
This article explores recent clinical developments of biological or targeted therapies in non-small cell lung cancer. Molecular research has given us a greater understanding of tumour biology and has ...
Elderly patients represent a significant and rising proportion of patients with Non-Small Cell Lung Cancer and historically they have been under-treated and under-represented in clinical trials. Incre...
At a time when our understanding of the molecular biology of cancer was supposed to lead to major advances in therapy, it is disappointing to report that the major lung cancer ‘story’ of 2002 (table o...
Background and Objectives: Lung cancer is the most common cancer and cancer related cause of death worldwide. However, the association between sleep duration and incident lung cancer has not been inve...
Background and objective Epidemiological studies have suggested that menstrual and reproductive factors may influence lung cancer risk, but the results are controversial. We therefore carried out a me...
MicroRNAs (miRNAs) are a class of non-coding RNAs that hybridize to mRNAs and induce either translation repression or mRNA cleavage. Recently, it has been reported that miRNAs could possibly play a cr...
Background and objective Pemetrexed have been approved for the treatment of patients affected by advanced non-small cell lung cancner (NSCLC) in progression after first-line chemotherapy. We evaluated...
Background and objective Non-small cell lung cancer (NSCLC) stages over IIIb still remain as an intractable disease. Survival rate of NSCLC stages over IIIb could be increased through chemotherapy and...
Background and objective cyclin D1 is a member of the cyclin family, and it has been proven that it plaied an important role in tumorigenesis, invasion and metastasis. We performed a retrospective stu...
Background and objective Approximately 30% of patients who are diagnosed with non-small cell lung cancer (NSCLC) are classified as N2 on the basis of metastasis to the mediastinal lymph nodes. The eff...
Background and objective Heparanase has been thought to be a good molecular marker of tumor, and the heparanase expression level correlated closely with tumor metastasis. In this study, we investigate...
The phamacogenetics is being used to predict whether the selected chemotherapy will be really effective and tolerable to the patient. Irinotecan, oxidized by CYP3A4 to produce inactive compounds, is u...
This study investigated quality of life (QOL) in patients with advanced non-small-cell lung cancer in an early phase of chemotherapy in a randomized phase III trial. QOL assessments for four domains (...
Breathlessness, fatigue, and anxiety are distressing symptoms for patients with advanced lung cancer, however, they are not relieved by palliative RT and are often viewed as neglected areas of clinica...

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