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An inhibitor of the mitotic kinase, MPS1, is selective towards pancreatic cancer cells
CIN70 MPS1 kinase inhibitor pancreatic cancer
2015/5/21
The abysmal five year pancreatic cancer survival rate of less than 6% highlights the need for new treatments for this deadly malignancy. Cytotoxic drugs normally target rapidly dividing cancer cells b...
目的： 研究RNA干扰(RNAi)效应对人卵巢癌细胞株HO8910PM和HO8910中bi-1基因表达的抑制作用和凋亡诱导作用。 方法： 把表达bi-1 shRNA的各重组干扰质粒转染到HO8910PM和HO8910细胞中，RT-PCR和Western blotting法检测bi-1基因mRNA和蛋白表达水平；流式细胞术和Hoechst 33258/PI荧光染色检测siRNA诱导细胞凋亡作用。结果...
Combination therapy with cell-binding domain,angiogenesis inhibitor and Ca2+ channel blocker in mice metastatic model
Metastasis Cell-binding domain Fibronectin Angiogenesis inhibitor Ca2+ channel blocker
2009/7/15
Background: In order to prevent tumor metastasis, we investigated more effective inhibition by combination therapy. The competition with native adhesion molecules by cell-binding domain, inhibition of...