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Depletion of Thymus-Derived CD4+CD25+ T Cells Abrogates the Suppressive Effects of α-galactosylceramide Treatment on Experimental Allergic Conjunctivitis
allergic conjunctivitis eosinophils regulatory T cells thymus α-galactosylceramide
2010/11/17
α-GalCer treatment significantly suppressed EC in the thymus-intact mice that had not been treated with anti-CD25 Ab. In contrast, α-GalCer treatment of thymectomized and anti-CD25 Ab-treated mice did...
Targeting Human Mast Cells Expressing G-Protein-Coupled Receptors in Allergic Diseases
allergic diseases bronchial asthma GPCRs human mast cells urticaria
2010/11/17
The G-protein-coupled receptors (GPCRs) are the largest known group of integral membrane receptor proteins and are the most common targets of pharmacotherapy. Mast cells (MCs) have been reported to pl...
Role of α-Galactosylceramide-activated Vα14 Natural Killer T Cells in the Regulation of Allergic Diseases
IFN-γ IgE Th2 responses Vα14 NKT cell α-Galactosylceramide
2010/11/18
Vα14 natural killer T (NKT) cells produce large amounts of both IL-4 and IFN-γ upon stimulation with a ligend, α-galactosylceramide (α-GalCer), and play a crucial role in various immune responses, inc...
Role of dendritic cells in Th1/Th2 balance: A novel therapeutic target of allergic diseases
dendritic cell monocyte chemotactic protein-1 OX40 ligand regulatory T cells Th2
2010/11/22
Considerable evidence supports the role of dendritic cells (DC) in the pathogenesis of allergic diseases. Dendritic cells, as the most potent antigen-presenting cells (APC) for the induction of primar...