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5'-三磷酸（5'-PPP）RNA被认为是一种病原体相关分子模式（PAMP），能够被模式识别受体RIG-I所识别，并引发宿主抗病毒的天然免疫反应。然而，鲜为人知的是，实际上，每秒钟哺乳动物细胞内会产生数百万个5'-PPP修饰的转录本。其中一些转录本，特别是由RNA聚合酶III介导的转录本，具有高度有序的结构并保持为5'-PPP，具有潜在激活RIG-I的能力。细胞是如何在保持足够的敏感性以快速检测到...
近日，山东大学齐鲁医院重症医学科副主任医师秦伟栋与齐鲁工业大学刘克印副教授在医工交叉方面再次合作，在国际顶级期刊Chemical Engineering Journal（IF=10.652，JCR1区）共同发表了题为“Rational design of a unique palladium coordination polymer with distinctive fluorescence an...
麻醉与危重急救研究室柯博文研究员课题组在Chemical Society Reviews (影响因子40.182)发表封面文章阐述生物正交策略实现前药激活（图）
麻醉 危重急救 研究室 柯博文 研究员 课题组 Chemical Society Reviews 影响因子 40.182 文章阐述 生物 策略 实现 药激活
2019/3/12
近日，四川大学华西医院麻醉与危重急救研究室柯博文研究员课题组在权威综述性杂志Chemical Society Reviews（影响因子40.182）上发表题为“Click and release: bioorthogonal approaches to “on-demand” activation of prodrugs”的封面文章。文章的通讯作者是四川大学柯博文研究员，第一作者为季兴跃博士，另一...
山东大学基础医学院孙金鹏教授团队研究成果在《Nature Chemical Biology》发表（图）
山东大学基础医学院 孙金鹏 教授 研究成果 Nature Chemical Biology
2018/8/27
近日，山东大学基础医学院膜受体药物研究团队孙金鹏教授课题组在GPCR信号转导研究中取得新进展，研究成果“Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin”8月17日在线发表于《Nature Chemical Biology》（1区期刊，5年影响因子IF: 13.99）。山东大学...
近日，国际著名期刊《Chemical Reviews》（2014年影响因子45.661）在线发表了上海交通大学系统生物医学研究院郭勋祥副研究员与化学化工学院张万斌教授合作的综述文章:“Copper-Catalyzed C−H Functionalization Reactions: Efficient Synthesis of Heterocycles”。论文全面系统地总结了金属铜催化...
天津大学雷晓光教授实验室在Nature Chemical Biology杂志上发表文章（图）
天津大学 雷晓光教授 实验室 Nature Chemical Biology杂志 发表文章
2012/12/29
2012年12月27日，天津大学药学院雷晓光教授实验室与美国西南医学中心及北京生命科学研究所王晓东教授实验室合作在国际化学生物学领域最具影响力的Nature Chemical Biology杂志上在线发表了题为：“Small-molecule activation of the TRAIL receptor DR5 in human cancer cells”的论文。该论文系统地阐述了通过化学生物...
浙江大学生理学课件04 Control of cells by chemical messengers
浙江大学 生理学 课件 04 Control of cells by chemical messengers
2009/10/12
浙江大学生理学课件04 Control of cells by chemical messengers。
Cytochrome P-450 Reductase Activities in the Liver Microsomes of Diabetic Rats Induced With Some Chemical Solvents
Cytochrome P-450 Reductase Diabetic Rats Chemical Solvents
2009/7/2
Cytochrome P-450 Reductase enzyme is an important enzyme providing electrons to the microsomal cytochrome P-450 enzyme system metabolizing some endogenous subtances forming in the liver, drugs, chemic...
Chemical Mediators and the Resolution of Airway Inflammation
airway inflammation asthma fish immune response lipid mediators
2010/11/17
Asthma pathobiology is remarkable for chronic airway inflammation that fails to spontaneously resolve. No curative therapy is currently available. A growing body of evidence indicates that, in health,...
Being a Wife of a Veteran with Psychiatric Problem or Chemical Warfare Exposure: A Preliminary Report from Iran
Chemical warfare Family relation Iran Mental health War Women
2010/4/8
Objective: The aim of the present study was to examine the relationship between marital satisfaction with psychological health in women whose husbands had either suffered from psychiatric problems or ...
November 15, 2006，Some of nature's most complicated chemistry takes place in the shoots and leaves of the tiny, unassuming periwinkle plant.MIT researchers studying the flowering plant have now figure...
Multiple Chemical Sensitivities Following Intolerance to Azo Dye in Sweets in a 5-year-old Girl
azo dye food additives inheritance multiple chemical sensitivities nonsteroidal anti-inflammatory drugs
2010/11/19
Open challenge tests with Tartrazine, aspirin and acetaminophen were positive, whereas skin prick tests using additives and NSAIDs and prick-prick tests using candies and jellybeans were all negative....
CHEMICAL DEPRECIATION OF CUSO4, NAPCP AND BAYLUSCIDE IN STANDING WATER
CHEMICAL DEPRECIATION CUSO4, NAPCP AND BAYLUSCIDE STANDING WATER
2010/2/4
In an attempt to determine the chemical losses of three common molluscicides, i.e. CuSO4, NaPCP and Bayer –73, in stagnant water, a solution of each of this molluscicide was applied to one or more B.t...