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Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production
vitamin C cyclooxygenase-2 oxidative stress Alzheimer’s disease stroke reactive oxygen species neuroinflammation NSAIDs 8-isoprostanes prostaglandin E synthase
2015/8/3
Inhibition of neuronal cyclooxygenase-2 (COX-2) and hence prostaglandin E2 (PGE2) synthesis by non-steroidal anti-inflammatory drugs has been suggested to protect neuronal cells in a variety of pathop...
Lipocalin-Type Prostaglandin D Synthase and Egg White Cystatin React with IgE Antibodies from Children with Egg Allergy
cystatin food allergy hen's egg white LC-MS/MS lipocalin-type prostaglandin D synthase
2010/11/12
Background: Ovalbumin, ovomucoid, ovotransferrin, lysozyme, and ovomucin are known to be major allergens found in egg white. Egg white protein is composed of over 30 proteins; many of which have neith...
Correlation between the Prostaglandin D2/E2 Ratio in Nasal Polyps and the Recalcitrant Pathophysiology of Chronic Rhinosinusitis Associated with Bronchial Asthma
aspirin-intolerant asthma bronchial asthma chronic rhinosinusitis prostaglandin D2 prostaglandin E2
2010/11/17
The concentrations of PGD2 were significantly higher in the nasal polyps of the CRS-ATA group. The concentrations of PGE2 were lowest in the nasal polyps of the CRS-AIA group. The PGD2/PGE2 ratio was ...
Role of Prostaglandin D2 and Its Receptors in the Pathophysiology of Asthma
asthma CRTH2 DP eosinophils lipid mediators single nucleotide polymorphisms
2010/11/17
Prostaglandin D2 (PGD2) is one of the most abundant lipid mediators present in the airways of asthmatics. However, little was known of the role it plays in the pathophysiology of asthma, until the ide...
Differentiation of naive human CD4+ T cells into Th2 cells: The role of prostaglandin E2
interleukin naive CD4+ T cells prostaglandin E2 T-helper 2 cells
2010/11/26
T-helper (Th) 2 cells, which produce interleukin (IL)-4, IL-5, IL-10 and IL-13 upon stimulation of their T cell receptors, play an important role in the development of human allergic diseases. However...
Prostaglandin D2 and interleukin-5 reduce CRTH2 surface expression on human eosinophils
CRTH2 eosinophils interferon-γ interleukin-4 interleukin-5 prostaglandin D2
2010/11/22
Background: Recently, a second prostaglandin D2 (PGD2) receptor, chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2), was identified. Because PGD2 was reported to have chemotac...