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P53 “master switch” remains top target in gene signaling network controlling cancer suppression（图）
P53 master switch top target gene signaling network controlling cancer suppression
2017/10/25
There are two important categories of genes involved in cancer development, oncogenes and tumor suppressor genes. When oncogenes gain function, e.g. through mutation, they actively promote cancer – dr...
Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP
Fragile X mGluR MPEP audiogenic seizures open field fmr1
2015/8/3
Fragile X Syndrome is the most common form of inherited mental retardation worldwide. A Fragile X mouse model, fmr1, with a disruption in the X-linked Fmr1 gene, has three substantial deficits observe...
Effects of suppression of bone turnover on cortical and trabecular load sharing in the canine vertebral body
trabecular bone cortical shell suppressed bone turnover
2014/12/4
The relative biomechanical effects of antiresorptive treatment on cortical thickness vs. trabecular bone microarchitecture in the spine are not well understood. To address this, T-10 vertebral bodies ...
A computational assessment of the independent contribution of changes in canine trabecular bone volume fraction and microarchitecture to increased bone strength with suppression of bone turnover
trabecular bone bone strength suppressed bone turnover
2014/12/4
This study addressed the effects of changes in trabecular microarchitecture induced by suppressed bone turnover—including changes to the remodeling space—on the trabecular bone strength–volume fractio...
The Application of Fat-Suppression MR Pulse Sequence in the Diagnosis of Bone-Joint Disease
Magnetic Resonance Imaging Fat Suppression Sequences Bone Joint
2013/1/29
Fat-suppression technology of magnetic resonance is very important in clinical practice.This article is written to interpret the principle, advantages/disadvantages and clinical applications of some r...
The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α
thymic epithelial microRNA network elevates threshold infection-associated
2012/2/1
Thymic output is a dynamic process, with high activity at birth punctuated by transient periods of involution during infection. Interferon-α (IFN-α) is a critical molecular mediator of pathogen-induce...
Suppression of MRI Truncation Artifacts Using Total Variation Constrained Data Extrapolation
Variation Constrained Data Extrapolation MRI
2009/9/4
The finite sampling of k-space in MRI causes spurious image artifacts, known as Gibbs ringing, which result from signal truncation at the border of k-space. The effect is especially visible for acquis...
Suppression of the high pressure nervous syndrome in human deep dives by He-N2-O2
human high pressure nervous syndrome
2009/7/20
Suppression of the high pressure nervous syndrome in human deep dives by He-N2-O2.
Effect of high pressure on EEG burst suppression dose of thiopental in rats
drug thiopental animal rat Electroencephalography heliox
2009/7/16
The anesthetic induction dose of thiopental in rats was studied at 1 ATA air, 1 ATA helium-oxygen (He-O2), 4 ATA air, and at 4 ATA air plus 67 ATA helium (71 ATA). The compression rate was 0.3 ATA/min...
An fMRI-MEG Integrative Neuroimaging Method: Improvements of its Accuracy and Robustness by Suppression of fMRI-invisible Coherent Activities
functional neuroimaging fMRI-MEG integrative analysis spatial filter
2009/6/8
One of possible problems in fMRI-MEG integrative analysis is mismatches between activated regions detected by fMRI and MEG. These mismatches cause serious degradation of estimation accuracy, especiall...
Suppression of cementum-like tissue formation on BMP-2-applied dentin surface by bisphosphonate
rhBMP-2 dentin resorption cementum-like tissue bisphosphonate
2009/5/20
We studied the effects of bisphosphonate administration on cementum-like tissue formation and dentin resorption induced by BMP-2 in rats.
Incadronate (1μg/kg/day) was administered intraperitoneally t...
Time-suppression test using a colorimetric probe（alamarBlue）that measures bacterial metabolic activity
Time-suppression test colorimetric probe（alamarBlue） bacterial metabolic activity
2009/3/2
We developed a time-suppression test using alamarBlue®, which will allow estimation of the cidal or static nature of antimicrobials very easily and quickly. As an example, the effects of vancomy...
Suppression of steroid receptor-chromatin interaction by inhibitors present in ammonium sulfate-fractionated rat testicular androgen receptor preparations
steroid receptor-chromatin interaction inhibitors present ammonium sulfate-fractionated rat
2009/2/23
Tritiated androgen receptor complex was partially purified by ammonium sulfate precipitation at 15 to 37% saturation from rat testicular or prostatic cytosols. A greater amount of prostatic tritiate...
Reversal of testicular function after prolonged suppression with an LHRH agonist in rhesus monkeys
testicular function prolonged suppression LHRH agonist rhesus monkeys
2009/2/23
Using subcutaneously implanted osmotic pumps, four male rhesus monkeys were continuously infused for 18 months with 100 micrograms/day of [(imBzl)-D-His6-Pro9-NEt]-LHRH (LHRH-A), a potent agonist of...
Stimulation of sperm production by human chorionic gonadotropin after prolonged gonadotropin suppression in normal men
sperm production human chorionic gonadotropin prolonged gonadotropin suppression normal men
2009/2/20
The precise hormonal milieu required for quantitatively normal spermatogenesis in man is unclear. The authors previously have shown that both supraphysiologic dosages of human chorionic gonadotropin...