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近日，基因治疗领域权威期刊《Human Gene Therapy》在线发表了我校生命科学学院医学遗传学研究中心梁德生课题组脊髓性肌肉萎缩症（spinal muscular atrophy, SMA）基因编辑治疗研究的最新成果。文章题为“Seamless genetic conversion ofSMN2 toSMN1 via CRISPR/Cpf1 and single-stranded olig...
The Effects of Insulin-Like Growth Factor-1 Gene Therapy and Cell Transplantation on Rat Acute Wound Model
IGF-1 Gene Therapy Cell Transplantation Fibroblast Wound Healing
2015/10/15
Background: Wound healing is a complex process. Different types of skin cells, extracellular matrix and variety of growth factors are involved in wound healing. The use of recombinant growth factors i...
Stent-Based Gene Therapy。
Molecular genetic,diagnosis,prevention and gene therapy in prostatic cancer: review article
Molecular genetic diagnosis prevention gene therapy prostate cancer
2009/12/15
The prostate is a small gland located below the bladder and upper part of the urethra. In developed countries prostate cancer is the second common cancer (after skin cancer), and also the second leadi...
About five years ago, Professor Janet Sawicki at the Lankenau Institute in Pennsylvania read an article about nanoparticles developed by MIT’s Daniel Anderson and Robert Langer for gene therapy, the i...
Nanoparticles target ovarian cancer--New gene therapy technique could fight late-stage tumors
ovarian cancer gene therapy technique late-stage tumors
2009/8/3
Tiny particles carrying a killer gene can effectively suppress ovarian tumor growth in mice, according to a team of researchers from MIT and the Lankenau Institute.The findings could lead to a new tre...
CANCER GENE THERAPY USING CYTOKINE AND CHEMOKINE GENES
Adenovirus CC chemokine granulocyte macrophage-colony stimulating factor interleukin-2 retrovirus secondary lymphoid tissue chemokine
2009/7/15
Surgical or radiotherapy-mediated eradication of tumors gives the best opportunity for cure, if the tumor is restricted to the primary sites. Chemotherapy is employed for disseminated disease but freq...
Gene Therapy in Human Breast Cancer
gene therapy breast cancer viral vectors vector targeting
2009/6/26
Gene therapy, being a novel treatment for many diseases, is readily applicable for the treatment of cancer patients. Breast cancer is the most common cancer among women. There are many clinical protoc...
Basic Studies on Gene Therapy with Ultrasound.
Recombinant Adenovirus Mediated Prostate-Specific Enzyme Pro-Drug Gene Therapy Regulated by Prostate-Specific Membrane Antigen（PSMA）Enhancer/Promoter
Cytosine deaminase prostate adenocarcinoma
2008/12/24
Gene directed enzyme pro-drug therapy (GDEPT) is one of the adjuvant therapeutic regimens for advanced prostate adenocarcinoma, and this research intended to explore how to apply targeting therapy o...
Gene Therapy to Enhance Condylar Growth Using rAAV-VEGF
Gene therapy rAAV VEGF Mandibular condylar growth
2008/10/29
Objective: To test the hypothesis that the introduction of specific vascular growth inducting genes would favorably affect mandibular condylar growth in Sprague-Dawley (SD) rats over a limited experim...
摘要以病毒和非病毒为载体的体细胞基因治疗是一种富有前景的治疗人类疾病的方法。然而，当前人类疾病基因治疗应用的限制主要是转基因方法的潜在风险、相对低效率和靶基因的胞内稳定性。因此，我们总结其为基因治疗的“3Y”问题——安全性(safety) 、有效性(efficacy) 和稳定性(stability)，并认为这也是人们应遵守的基因治疗的“3Y”原则。
Abstract:Somatic gene t...
专著信息
书名
Vascular Endothelial Growth Factor Gene Therapy Enhances Survival of Ischemic Random Skin Flaps in the Rats
语种
英文
撰写或编译
作者
杨立文,张吉翔
第一作者单位
出版社
《British Journal of Plastic Surgery》in press
出版地
出...
Experimental Gene Therapy “Abolishes” Arthritis Pain and Lessens Joint Damage（图）
Gene Therapy Arthritis osteoarthritis
2007/5/28
May 25, 2007，Early-stage research has found that a new gene therapy can nearly eliminate arthritis pain, and significantly reduce long-term damage to the affected joints, according to a study publishe...
Gene Therapy: Opportunities for Pharmacy in the 21st Century
Gene Therapy Opportunities Pharmacy 21st Century
2016/3/10
Throughout the history of the profession, pharmacy has adopted technologies which have eventually become recognized responsibilities of the pharmacist. Genetic technologies, which to date, have primar...