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FlexStem: Improving Predictions of RNA Secondary Structures With Pseudoknots by Reducing the Search Space
RNA Secondary Structures Pseudoknots
2010/12/17
RNA secondary structures with pseudoknots are often predicted by minimizing free energy, which is proved to be NP-hard. Due to kinetic reasons the real RNA secondary structure often has local instead ...
A Flexible Stem-Based Local Search Algorithm for Predicting RNA Secondary Structures Including Pseudoknots
Flexible Stem-Based Local Search Algorithm Predicting RNA Secondary Structures
2010/12/17
We demonstrate a new algorithm named FlexStem to predict RNA secondary structures with pseudoknots. Our approach is based on the free energy minimization criterion, and
utilizes a sophisticated energ...