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Quantity and source of dietary protein influence metabolite production by gut microbiota and rectal mucosa gene expression: a randomized, parallel, double-blind trial in overweight humans
dietary protein protein source high-protein diet gut microbiota,
2018/11/16
Background: Although high-protein diets (HPDs) are frequently consumed for body-weight control, little is known about the consequences for gut microbiota composition and metabolic activity and for lar...
Skeletal muscle metabolic gene response to carbohydrate feeding during exercise in the heat
Mitochondrial biogenesis PGC-1α UCP3
2015/7/28
Heat stress down-regulates mitochondrial function, while carbohydrate supplementation attenuates
the exercise induced stimulation of mitochondrial biogenesis in humans. The effects of exogenous carbo...
Isoleucine-to-methionine substitution at residue 148 variant of PNPLA3 gene and metabolic outcomes in gestational diabetes
NAFLD PNPLA3 fatty liver iver enzymes GDM fatty liver ransaminase ALT trial
2018/12/20
Background: A single nucleotide polymorphism (SNP) of the patatin-like phospholipase-3 (PNPLA3)/adiponutrin gene (rs738409 C>G) is strongly associated with nonalcoholic fatty liver disease; to our kno...
Isoleucine-to-methionine substitution at residue 148 variant of PNPLA3 gene and metabolic outcomes in gestational diabetes
NAFLD PNPLA3 fatty liver liver enzymes GDM fatty liver transaminase ALT trial
2018/12/20
Background: A single nucleotide polymorphism (SNP) of the patatin-like phospholipase-3 (PNPLA3)/adiponutrin gene (rs738409 C>G) is strongly associated with nonalcoholic fatty liver disease; to our kno...
Variation in the SLC23A1 gene does not influence cardiometabolic outcomes to the extent expected given its association with L-ascorbic acid
L-ascorbic acid cardiometabolic traits confounding genetic variants reverse causation
2018/12/20
Background: Observational studies showed that circulating L-ascorbic acid (vitamin C) is inversely associated with cardiometabolic traits. However, these studies were susceptible to confounding and re...