搜索结果: 1-7 共查到“细胞生物学 Differentiation”相关记录7条 . 查询时间(0.06 秒)
代谢重编程是肿瘤的基本特征之一。肿瘤细胞即使在氧气充足的条件下仍优先通过糖酵解途径而不是线粒体氧化磷酸化产生能量，这种现象被称为Warburg效应。这种异常的代谢方式导致肿瘤细胞过度依赖葡萄糖代谢产生乳酸，并同时抑制了三羧酸（TCA）循环等氧化代谢途径，减少了细胞内氧化压力并同时产生大量用于生物合成的代谢中间体，促进肿瘤细胞的快速增殖。肿瘤细胞如何协调糖酵解以及TCA循环也一直是肿瘤代谢领域的重点...
浙江大学生命科学研究院张龙实验室在Cell Death & Differentiation发表论文阐述SUMO介导的核受体泛素化调控巨噬细胞凋亡（图）
浙江大学生命科学研究院 张龙实验室 Cell Death & Differentiation SUMO介导 核受体泛素化 巨噬细胞凋亡
2017/7/6
2017年6月16日，张龙实验室在Cell Death & Differentiation发表题为“SUMO-triggered ubiquitination of NR4A1 controls macrophage cell death”的研究论文，揭示SUMO介导的核受体泛素化调控巨噬细胞凋亡。孤核受体NR4A1（nuclear receptor subfamily4,group A,memb...
Death associated lepidopteran DALP, and its mammalian ortholog Hic-5, act as negative regulators of muscle differentiation
Vertebrates muscle differentiation muscle cells trunk limbs satellite cells cell apoptosis molecular regulation gene
2014/12/11
During muscle differentiation in vertebrates, myoblasts initially form in somites and then migrate to proper locations in the trunk and limbs. Once there, these cells are faced with one of three choic...
NON-CANONICAL NOTCH SIGNALING REGULATES ACTIVATION AND DIFFERENTIATION OF PERIPHERAL CD4+ T CELLS
Notch non-canonical T cell NF-kB mTOR activation differentiation cross-talk
2014/12/10
Cleavage of the Notch receptor via a γ-secretase, results in the release of the active intra-cellular domain of Notch that migrates to the nucleus and interacts with RBP-JΚ, resulting in the activatio...
Analysis of differentiation capacity of Cfp1 null embyronic stem cells
Stem Cells Cell Differentiation Epigenetics DNA Methylation Mice Cardiomyocytes Neurons Leukemia Inhibitory Factor
2015/5/22
Epigenetics is defined as “the study of stable, often heritable, changes that influence gene expression that are not mediated by DNA sequence” (Fingerman et al., 2013). Epigenetic marks such as covale...
SIRT1 DEFICIENCY COMPROMISES MOUSE EMBRYONIC STEM CELL DIFFERENTIATION, AND EMBRYONIC AND ADULT HEMATOPOIESIS IN THE MOUSE
Mouse Embryonic Stem Cell Hematopoietic Cell Differentiation
2015/5/21
SIRT1 (Sirtuin 1) is a founding member of a family of seven proteins and histone deacetylases. It is involved in cellular resistance to stress, metabolism, differentiation, aging, and tumor suppressio...
A Structured Population Model of Cell Differentiation
Structured Population Model Cell Differentiationv
2011/1/5
We introduce and analyze several aspects of a new model for cell differentiation. It assumes that differentiation of progenitor cells is a continuous process. From the mathematical point of view, it i...