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Scientists Are First to See Elements Transform at Atomic Scale
Scientists Elements Transform Atomic Scale
2015/6/18
Chemists at Tufts University’s School of Arts and Sciences, collaborating with PerkinElmer and UCL (University College London), have witnessed atoms of one chemical element morph into another for the ...
氨基酸广义疏水标度(GH-scale)用于HLA-A*0201限制性CTL表位的定量预测研究
氨基酸广义疏水标度 HLA-A*0201 CTL表位 定量构效关系 遗传-偏最小二乘回归
2013/10/21
天然氨基酸149个疏水性质经主成分分析得到了一种新氨基酸描述子——氨基酸广义疏水标度(GH-scale). 用GH-scale结合遗传偏最小二乘(GPLS)算法对152个HLA-A*0201限制性CTL表位进行定量构效关系(QSAR)研究. 所建模型拟合及交叉检验复相关系数分别为<=0.813sPA CLASS="formnla">和Q2 = 0.725. 研究表明, 疏水作用在CTL表位与HLA...