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Identification of Histone Deacetylase 2 as a Functional Gene for Skeletal Muscle Development in Chickens
Histone Deacetylas Post Genome-Wide Association Study Gene Expression Myogenesis
2016/5/19
A previous genome-wide association study (GWAS) exposed histone deacetylase 2 (HDAC2) as a possible candidate gene for breast muscle weight in chickens. The present research has examined the possible ...
组蛋白去乙酰化酶SIR2与染色质沉默The Histone Deacetylase Activity of SIR2 and Chromatin Silencing
组蛋白去乙酰化酶 SIR2 染色质沉默 组蛋白乙酰转移酶 NAD
2007/12/31
摘要DNA的大部分区域通过包装成特殊的染色质结构而失去活性称为染色质沉默。这些特殊的染色质结构在维持染色体结构稳定和基因调控中起重要作用。有实验表明，沉默染色质的组蛋白H3和H4的的氨基末端尾部相对于基因组的其他区域是低乙酰化的。组蛋白去乙酰化酶SIR2（silent information regulator2）是参与染色质沉默的一种重要的蛋白质。SIR2具有两种相关联的酶活性，组蛋白去乙酰化酶...