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端粒（Telomere）是真核细胞染色体末端的多重复序列（TTAGGG）及其结合蛋白组成的特殊结构（图1），主要功能是保护染色体末端免于降解、融合和退化，从而保证细胞DNA及相关遗传信息的稳定和完整。端粒长度（Telomere length, TL）随着细胞分裂次数的增加而不断缩短，当TL不能再缩短时，细胞也就无法继续分裂，进而走向衰老、死亡或癌变。因此，TL是指征衰老和疾病（糖尿病、肺纤维化、心...
【致远名家讲堂】第三讲丨美国杜克大学何胜洋院士：Disease-Microbiome-Climate interactions in plants（图）
致远名家讲堂 第三讲 何胜洋 美国杜克大学 病害三角 植物病原物
2023/12/11
2023年9月13日，中国农业大学植物保护学院于植保楼报告厅开展第三期致远名家讲堂活动，特邀请美国科学院院士、美国杜克大学何胜洋教授主讲。本次活动线上线下同步进行，逾300名师生现场听讲，500余人参与线上直播活动。本次活动由彭友良教授和孙文献教授主持。
南京农业大学农学院《Plant Physiology》发表华健教授课题组“CHROMATIN REMODELING 11-dependent nucleosome occupancy affects disease resistance in rice”（图）
华健 基因转录 蛋白修饰
2023/10/28
染色质重塑主要包括围绕核小体的组蛋白修饰和染色质重塑蛋白介导的染色质构型调控。染色质重塑介导的基因转录表达调控是植物基因转录调控最重要的调控机制之一。然而，目前对于病原菌侵染诱导的寄主植物核小体动态变化及其与基因转录表达的关系尚不清楚。
New method tracking changes in blood vessels could advance brain disease detection（图）
血管变化 脑部疾病 成像技术 神经退行性疾病
2023/6/26
A new imaging technique opens a path toward long-term study of blood vessels in aging brains and could help predict neurodegenerative diseases decades before symptoms begin.
The following press release was issued today by the Broad Institute of MIT and Harvard.
New technologies reveal cross-cutting breakdowns in Alzheimer’s disease（图）
阿尔茨海默病 交叉细分 单细胞分析 脑细胞
2023/6/21
After decades of fundamental scientific and drug discovery research, Alzheimer’s disease has remained inscrutable and incurable, with a bare minimum of therapeutic progress. But in a new review articl...
清华大学医学院梁冠翔课题组发表题为“The pediatric virome in health and disease”长文综述（图https://www.med.tsinghua.edu.cn/info/1049/3980.htm）（图）
人体微生物 清华大学医学院 噬菌体
2023/6/16
2022年5月11日，清华大学医学院基础医学系、清华大学医学院传染病研究中心、清华-北大生命科学联合中心梁冠翔课题组与宾夕法尼亚大学医学院Frederic Bushman课题组受邀合作为国际知名学术期刊《Cell Host & Microbe》15周年纪念特刊撰写题为“The pediatric virome in health and disease”的综述文章。该文章系统概述了人类病毒组从起源...
In an oceanic omen for climate change’s intensifying effects, Cornell-led research shows that seagrass – through large swaths of intertidal meadows in the Pacific Northwest – suffers from a lesion-fil...
Study reports repair of mitochondrial recycling defect linked to Parkinson’s disease
dopamine PD mitochondria recovery
2021/8/11
A study in mice shows that an experimental small molecule helped restore the removal of damaged mitochondria from dopamine-producing brain cells.
Terence D. Capellini has been interested in how joints work for almost three decades. Part of it is due to personal experience, as he suffered several joint injuries as a college ice hockey player and...
New gene-editing technique shows promise against sickle cell disease（图）
镰状细胞性贫血 基因编辑技术 一次性治疗
2023/6/21
Ateam of researchers led by scientists from Harvard and the Broad Institute used a new gene-editing technique to successfully treat sickle cell disease in mice. This advancement could one day lead to ...
Gene editing, or purposefully changing a gene’s DNA sequence, is a powerful tool for studying how mutations cause disease, and for making changes in an individual’s DNA for therapeutic purposes. A nov...
近日，中南大学湘雅医院临床药理研究所张伟教授团队在细胞生物学权威期刊《Cell Death & Disease》（即时IF:8.104）上连续发表两篇鼻咽癌放疗基因组学原创性基础研究论著。
Researchers look for human disease solutions in opossums（图）
human disease solutions opossums
2021/4/9
Scientists have examined the immune system of an unusual group of mammals, which includes a small South American opossum, to find solutions that evolution has produced to fight disease-causing pathoge...
近日，山西医科大学山西省出生缺陷和细胞再生重点实验室解军教授团队在 《Cell Death & Disease》杂志发表了最新研究成果“Aberrant Gcm1 expression mediates Wnt/β-catenin pathway activation in folate deficiency involved in neural tube defects”。