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糖尿病的发病率及死亡率逐年升高,作为糖尿病的重要慢性并发症之一,糖尿病心肌病的研究不断深入。糖尿病心肌病的发病机制复杂,其中氧化应激和DNA损伤是其启动和持续因素。脱嘌呤/脱嘧啶核酸内切酶1 (APE1)的两个主要功能是氧化还原与DNA修复,目前许多研究已经证实其在癌症、免疫及心血管疾病等领域起到了不可忽视的作用。APE1与糖尿病心肌病发生发展及预后紧密相连。本文主要根据近年来国内外关于APE1在...
探讨树突状细胞联合细胞因子诱导的杀伤细胞(dendritic cells/cytokine induced killer cells adoptive immunotherapy,DC-CIK)联合FOLFOX6方案(奥沙利铂+亚叶酸钙+5-氟尿嘧啶)治疗老年结直肠癌患者的疗效及对人类阳离子抗菌蛋白18(human cationic antimicrobial protein 18,hCAP18)...
The DNA Base Excision Repair (BER) pathway repairs DNA damaged by endogenous and exogenous agents including chemotherapeutic agents. Removal of the damaged base by a DNA glycosylase creates an apurini...
Human apurinic/apyrimidinic endonuclease 1 (hApe1) is a multi-functional protein having two major functions: apurinic/apyrimidinic endonuclease activity for DNA damage repair and redox activity for ge...
Ape1 is a molecule with dual functions in DNA repair and redox regulation of transcription factors. In Ape1-deficient mice, embryos do not survive beyond embryonic day 9, indicating that this molecule...
The DNA base excision-repair pathway is responsible for the repair of DNA damage caused by oxidation/alkylation and protects cells against the effects of endogenous and exogenous agents. Removal of th...
Background: The mechanism by which heat sensitizes mammalian cells to ionizing radiation remains to be elucidated. We determined whether base excision repair (BER) is involved in heat-radiosensitizati...
Peripheral neuropathy is one of the major side-effects of the anticancer drug, cisplatin. Although previous work suggests that this neuropathy correlates with formation of DNA adducts in sensory neuro...
Oxidative DNA damage has been implicated in a number of central nervous system pathologies. The base excision repair (BER) pathway is one of the most important cellular protection mechanisms that resp...
Apurinic apyrimidinic endonuclease/redox effector factor 1 (APE1/Ref-1) protects cells from oxidative stress by acting as a central enzyme in base excision repair pathways of DNA lesions and through i...
APE1/Ref-1 (hereafter, APE1), a DNA repair enzyme and a transcriptional coactivator, is a vital protein in mammals. Its role in controlling cell growth and the molecular mechanisms that fine-tune its ...
Apurinic apyrimidinic endonuclease redox effector factor-1 (APE1/Ref-1) is involved both in the base excision repair (BER) of DNA lesions and in the eukaryotic transcriptional regulation. APE1/Ref-1 i...
Apurinic endonuclease 1/redox effector factor-1 (Ape1/Ref-1 or Ape1) is an essential protein with two distinct functions. It is a DNA repair enzyme in the base excision repair (BER) pathway and a redu...
APE1/Ref-1 (APE1), the mammalian ortholog of Escherichia coli Xth, and a multifunctional protein possessing both DNA repair and transcriptional regulatory activities, has a pleiotropic role in control...
比较APE1-konckdown骨肉瘤HOS细胞miRNAs表达谱的差异,初步探讨APE1可能调控的miRNAs及其涉及的功能通路。 方法 利用Ad5/F35-APE1 siRNA腺病毒敲低骨肉瘤HOS细胞中APE1的表达,采用miRNA芯片检测敲低组和对照组miRNAs表达谱的改变,qRT-PCR验证,并利用生物信息学分析差异miRNAs涉及的功能。 结果 ...

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