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中国科学院动物研究所专利：内源性的非编码小RNAs及其应用
中国科学院动物研究所 专利 内源性 非编码 小RNAs
2024/5/31
本发明提供一种微小RNA即miR 644及其前体序列在诊断、预防、治疗和/或预后评估恶性肿瘤中的用途。本发明提供的微小RNA为包含SEQ ID NO：1所示的核苷酸序列的核酸或者其生物活性功能片段或变体：5′ AGUGUGGCUUUCUUAGAGC 3′，所述微小RNA的前体为包含SEQ ID NO：3所示的核苷酸序列的核苷酸或者其生物活性功能的片段或变体。该微小RNA可以作为一种新型的药物组合物...
大脑衰老的生物学机理十分复杂，受到遗传、年龄和环境等多个因素的调控和影响，其中随年龄和环境等因素而变化的表观遗传调控被认为是重要的调控环节之一。基因组中大约90% DNA 都具有转录活性，但其中仅有1.5%的基因能够编码蛋白质，而环状非编码RNAs (circRNAs)即属于不具有编码功能的非编码RNAs范畴。近年来，越来越多的研究证据揭示circRNAs 介导的表观遗传调控在机体的诸多生命过程和...
大脑发育和老化过程十分复杂，涉及遗传、年龄和环境等多个因素的调控和影响，其中由年龄和环境等主要因素导致的表观遗传调控的变化被认为是重要环节之一。基因组中大约90% DNA都具有转录活性，这当中仅有1.5%的基因具有编码蛋白质的功能，而大部分是不具有编码蛋白质功能的，其中就包括长链非编码RNAs (lncRNAs)。近年来，越来越多的研究证据揭示lncRNAs介导的表观遗传调控在机体的许多生命过程和...
You are cordially invited to participate in a new conference on Regulatory & Non-Coding RNAs to be held at Cold Spring Harbor Laboratory. The opening session will begin at 7:30 pm on Tuesday, August 2...
RNA-dependent RNA polymerase of turnip crinkle virus and the effect of coat protein on the replication of subviral RNAs
Biological sciences
2015/1/28
In this dissertation, I report the functions of the TCV coat protein in TCV viral and subviral RNA replication using in vivo and in vitro systems. In chapter 2, I present my results on construction of...
Box C/D small nucleolar RNAs: Biogenesis, structure and utilization for in vivo ribozyme studies
Eukaryotic cells biological origin yeast capsule
2014/12/11
Eukaryotic cells contain scores of small nucleolar RNAs (snoRNAs), which are required for maturation of pre-rRNA. Two large snoRNA families exist defined by vital box C/D and box H/ACA motifs. The goa...
The major function of eukaryotic small nucleolar RNAs is nucleotide modification in ribosomal RNA
Small nucleoli element RNA
2014/12/11
Small nucleolar RNAs (snoRNAs) can be divided into two large families based on conserved sequence elements. These two classes are the box C/D snoRNAs and the box H/ACA snoRNAs. At the onset of this th...
Symptom modulation by subviral RNAs associated with turnip crinkle virus
Plants the virus the virus symptoms radish knit virus satellite RNA and toxicity
2014/12/11
Many plant RNA viruses provide replication and encapsidation functions for one or more subviral RNAs that can modulate the symptoms of the associated helper virus. In this dissertation, I report my st...
Inhibition of protein synthesis in Escherichia coli by expression of RNAs containing multiple ribosome binding sites
To get together the biosynthesis of chemical biological synthesis mRNA
2014/12/11
Biologically synthesized poly(α,L-glutamic acid) (PLGA) can be chemically modified to form monodisperse poly(γ-benzyl α,L-glutamate) (PBLG). This material shows rare smectic ordering where macromolecu...
细胞机器是如何对基因调控的小RNAs分子前体进行分选的
细胞机器 基因调控 小RNAs分子前体
2010/8/18
这个研究由冷泉港实验室的Benjamin Czech负责，他提出了一个问题：当双链RNAs进入RNAi通路时，展开的过程中是否可以观察到截然不同的模式。RNAi简称为RNA干扰，是双链RNA的一个生物学反应，能够在调节基因表达时达到顶峰。这种现象已经在生物体中普遍存在，从植物到蠕虫、到果蝇还有人类。
拟南芥六个新的small RNAs 的克隆和功能预测
拟南芥 small RNA PCR 克隆
2009/5/27
以模式植物拟南芥为例, 建立了一种克隆small RNA 分子的技术平台, 为今后开展small RNA 分子的生物学功能研究提供技术支撑。通过用抗病信号分子水杨酸(SA) 处理拟南芥叶片后, 进行small RNA 分子群体的分离与接头连接、PCR 扩增、T - 载体克隆与检测、测序分析和生物信息学分析等一系列实验, 成功地克隆了一些small RNAs, 并对其表达和功能进行了分析。
Small RNAs yield great amounts of data from ocean microbe samples
RNAs data ocean microbe samples CEE
2009/5/20
An ingenious new method of obtaining marine microbe samples while preserving the microbes' natural gene expression has yielded an unexpected boon: the presence of many varieties of small RNAs -- snipp...
大鼠4.5S RNAs的cDNA克隆与序列分析
大鼠 4.5S RNAs RT-PCR
2007/12/11
利用RT-PCR方法，首次从大鼠肝脏细胞总RNA中扩增出4.5S RNAs的cDNA。该cDNA被克隆到pGEM3Zf(+)质粒上，经酶切电泳鉴定，然后测序。与报道的小鼠和仓鼠4.5S RNAs序列进行了比较研究，并对该分子的结构特点进行了初步分析。
Co-expression and Sequence Determination of Estrogen Receptor Variant Messenger RNAs in Swine Uterus
Gene Expression Estrogen Receptor Pig Reproduction
2016/4/14
Steroid hormones and their receptors play an important role in reproductive process. Estrogen is intimately involved with pregnancy and its function is mediated through the estrogen receptor which has...