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Infectious disease ecology,forest biodiversity,urban ecology featured at upcoming conference
Infectious disease ecology forest biodiversity urban ecology featured
2015/8/4
The ecology of cities across the U.S., spread of infectious diseases such as Ebola, worldwide forests under siege, and how life thrives in Earth's critical zone are among the topics featured at the 20...
The role of the Borrelia oxidative stress regulator protein in virulence gene expression of the Lyme disease spirochete
Borrelia burgdorferi, BosR RpoS
2015/5/21
The Lyme disease agent, Borrelia burgdorferi, has a complex system that allows it to thrive in the harsh and distinct environments of its tick vector and mammalian host. Although it has been known for...
An IL-4-dependent macrophage-iNKT cell circuit resolves sterile inflammation and is defective in mice with chronic granulomatous disease
macrophage-iNKT cel chronic granulomatous disease
2015/5/21
The immune system initiates tissue repair following injury. In response to sterile tissue injury, neutrophils infiltrate the tissue to remove tissue debris and subsequently undergo apoptosis. Proper c...
The regulation of allergic airway disease by type V collagen-induced tolerance
IL-17 Type V Collagen
2015/5/21
Tissue remodeling and complement activation are asthma hallmarks. Type V collagen [col(V)], a cryptic antigen, becomes exposed during lung remodeling. IL-17 is key to anti-col(V) immunity, and regulat...
Long-term study on ticks reveals shifting migration patterns, disease risks
ticks shifting migration patterns disease risks
2015/5/25
Over nearly 15 years spent studying ticks, Indiana University's Keith Clay has found southern Indiana to be an oasis free from Lyme disease, the condition most associated with these arachnids that are...
Penn Researchers Develop Custom Artificial Membranes to Study the Molecular Basis of Disease
Penn Researchers Custom Artificial Membranes the Molecular Basis
2015/5/25
Decorating the outside of cells like tiny antenna, a diverse community of sugar molecules acts like a telecommunications system, sending and receiving information, recognizing and responding to foreig...
Earth Day: Disease spread among species is predictable
Earth Day Disease spread predictable
2015/4/30
On Earth Day, a study of disease dynamics in a California grassland has revealed fundamental principles underlying the spread of pathogens, or disease-causing microbes, among species.The results, anno...
Hibernation season over, will disease-ridden bats emerge from caves and mines this spring?（图）
Hibernation season over disease-ridden bats caves mines
2015/3/25
The following is part 15 in a series on the NSF-NIH-USDA Ecology and Evolution of Infectious Diseases (EEID) Program. See parts: one, two, three, four, five, six, se...
In a warmer world, ticks that spread disease are arriving earlier, expanding their ranges（图）
warmer world ticks that spread disease arriving earlier
2015/3/4
In the northeastern United States, warmer spring temperatures are leading to shifts in the emergence of the blacklegged ticks that carry Lyme disease and other tick-borne pathogens. At the same time, ...
Human Niemann-Pick Type C2 Disease Protein Expression, Purification and Crystallization
Niemann-Pick type C2 NPC2 Structure Expression Crystallization Purification
2014/12/12
Niemann-Pick type C2 (NPC2) protein is a soluble protein that binds unesterified cholesterol. The protein helps transport unesterified cholesterol in tandem with the membrane protein Niemann-Pick type...
The Parkin-like ubiquitin E3 ligase Ariadne-1 in the mammalian brain: Potential implications for neurodegenerative disease
Parkinson's disease movement disorders dopaminergic neurons gene encoding protein ubiquitin proteasome system enzyme E3 ubiquitin ligase
2014/12/10
Parkinson’s disease (PD) is a movement disorder characterized by a massive loss of dopaminergic neurons of nigrostriatal origins. Several genes associated with familial cases of PD encode proteins tha...
NOVEL STRATEGIES TO MODULATE SYNAPTIC COMMUNICATION AND INVESTIGATE THE ROLE OF HDAC6 IN ALZHEIMER’S DISEASE
Photochemistry GABA_A receptors Alzheimer's disease Tau HDAC6
2014/12/10
Neuronal communication is mediated by chemical signaling at the synapse. The underlying molecular mechanisms of learning and memory are poorly understood. Very few tools are available to study how mem...
Pharmacological Chaperoning in Fabry Disease
Pharmacological Chaperone Fabry Disease X-ray Crystallography
2014/12/9
Fabry Disease is an X--‐linked lysosomal storage disorder characterized by a variety of symptoms including hypohydrosis, seizures, cardiac abnormalities, skin lesions, and chronic pain. These symptoms...
Impact of a 6-wk olive oil supplementation in healthy adults on urinary proteomic biomarkers of coronary artery disease, chronic kidney disease, and diabetes (types 1 and 2): a randomized, parallel, controlled, double-blind study
Mediterranean diet coronary artery disease olive oil phenolics proteomic biomarkers
2018/12/19
Background: Olive oil (OO) consumption is associated with cardiovascular disease prevention because of both its oleic acid and phenolic contents. The capacity of OO phenolics to protect against low-de...
Palmitoleic acid is elevated in fatty liver disease and reflects hepatic lipogenesis
palmitoleic fatty acid VLDL triacylglycerol biomarker lipogenesis stearoyl-CoA desaturase
2018/12/19
Background: Biochemical evidence has linked the coordinate control of fatty acid (FA) synthesis with the activity of stearoyl-CoA desaturase-1 (SCD1). The ratio of 16:1n–7 to 16:0 [SCD1(16)] in plasma...