搜索结果: 16-30 共查到“知识库 骨骼生理学”相关记录44条 . 查询时间(2.343 秒)
Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women: a randomized controlled trial
isoflavone bone turnover bioavailability probiotics osteopenia postmenopause equol bone density
2018/11/16
Background: Female age-related estrogen deficiency increases the risk of osteoporosis, which can be effectively treated with the use of hormone replacement therapy. However, hormone replacement therap...
A systematic review and meta-analysis of the effects of isoflavone formulations against estrogen-deficient bone resorption in peri- and postmenopausal women
isoflavone bone estrogen deficiency osteopenia osteoporosis
2018/11/19
Background: Age-related estrogen deficiency leads to accelerated bone resorption. There is evidence that, through selective estrogen receptor modulation, isoflavones may exert beneficial effects again...
A systematic review and meta-analysis of the effects of isoflavone formulations against estrogen-deficient bone resorption in peri- and postmenopausal women
isoflavone, bone, estrogen deficiency, osteopenia, osteoporosis
2018/11/16
Background: Age-related estrogen deficiency leads to accelerated bone resorption. There is evidence that, through selective estrogen receptor modulation, isoflavones may exert beneficial effects again...
Long-term weight-loss maintenance in obese patients with knee osteoarthritis: a randomized trial
weight loss maintenance diet obesity knee osteoarthritis low-energy diet weight cycling body composition blood pressure
2018/11/16
Background: A formula low-energy diet (LED) reduces weight effectively in obese patients with knee osteoarthritis, but the role of LED in long-term weight-loss maintenance is unclear.
Long-term weight-loss maintenance in obese patients with knee osteoarthritis: a randomized trial
weight loss maintenance diet obesity knee osteoarthritis low-energy diet weight cycling body composition blood pressure
2018/11/19
Background: A formula low-energy diet (LED) reduces weight effectively in obese patients with knee osteoarthritis, but the role of LED in long-term weight-loss maintenance is unclear.
Challenges in defining the role of dietary protein in bone health
Challenges bone health dietary protein
2018/11/14
The systematic review of dietary protein and bone health and falls in the current issue of the Journal by Shams-White et al. (1) is thorough and timely. Their key findings are that dietary protein int...
Dietary protein and bone health: a systematic review and meta-analysis from the National Osteoporosis Foundation
protein bone health osteoporosis bone density diet
2018/11/14
Background: Considerable attention has recently focused on dietary protein’s role in the mature skeleton, prompted partly by an interest in nonpharmacologic approaches to maintain skeletal health in a...
Peripheral skeleton bone strength is positively correlated with total and dairy protein intakes in healthy postmenopausal women
bone fragility bone microstructure dairy products finite element analysis fracture risk HR-pQCT nutrition osteoporosis protein intake
2018/11/12
Background: Bone mineral content (BMC) and bone mineral density (BMD) are positively correlated with dietary protein intakes, which account for 1–8% of BMC and BMD variances. However, the relation bet...
壳聚糖微球/小牛松质骨支架复合缓释体系的制备及体外生物活性评价
壳聚糖 微球体 药物释放系统 小牛松质骨
2018/12/3
目的：通过乳液交联法合成壳聚糖微球并负载骨形态发生蛋白（bone morphogenetic protein-2，BMP-2），再将其复合于脱细胞基质的小牛松质骨支架，制备壳聚糖微球/小牛松质骨支架复合缓释体系。方法： 使用红外光谱仪、扫描电镜对合成的复合缓释系统进行结构表征和形貌观察，并对微球的包封率和载药量进行检测。用动态浸泡的方法来检测BMP-2的体外释放特征，通过体外检测复合体系的细胞毒性...
目的：建立磁共振（magnetic resonance imaging，MRI）T1加权像（T1-weighted imaging，T1WI）图像中肌肉脂肪化程度的色阶直方图评估法，分析其临床应用价值。方法： 对25例抗肌萎缩蛋白病患者行大腿肌肉MRI检查，分别采取直视分级法和色阶直方图评估法对肌肉脂肪化程度进行评估，比较两种方法的肌肉脂肪化评估结果及其与年龄、肌力的相关性。用组内相关系数检验两种...
骨质疏松是老年人群中最常见的代谢性骨病，据统计，20%的绝经后女性会发生不同程度的骨质疏松［1］。椎体压缩骨折是骨质疏松最常见的合并症之一，是影响老年人生活质量的重要因素。椎体压缩骨折好发于脊柱胸腰段，临床上表现为不同程度的腰背部疼痛，诊断主要依靠脊柱正侧位X线，观察骨折后椎体楔形变现象。
Free 25-hydroxyvitamin D is low in obesity, but there are no adverse associations with bone health
bone density bone turnover half-life obesity vitamin D vitamin D–binding protein
2018/11/30
Background: The mechanism and clinical significance of low circulating 25-hydroxyvitamin D [25(OH)D] in obese people are unknown. Low total 25(OH)D may be due to low vitamin D–binding proteins (DBPs) ...
软骨中硫化氢含量及其对白介素1β诱导的软骨细胞基质金属蛋白酶13表达的抑制作用
硫化氢 骨关节炎 基质金属蛋白酶 软骨疾病
2018/11/29
目的：研究关节液及关节软骨中硫化氢（hydrogen sulfide，H2S）及其合成酶的含量和变化，以及H2S对白介素1β（interlukin-1β，IL-1β）诱导的软骨细胞人基质金属蛋白酶-13（matrix metalloproteinase 13，MMP-13）表达的影响。方法：收集在北京大学第一医院行膝关节手术（关节镜手术或膝关节置换术）患者的关节液及废弃的关节软骨，用亚甲基蓝法检测...
NELL-1: 高效特异的新型生长因子
Nell1蛋白 骨形态发生蛋白质 骨生成 软骨发生
2018/11/30
骨与其他组织的再生往往需要种子细胞、支架材料和相关生长因子三方面的参与，而生长因子作为维持微环境的重要组成部分，对于组织再生起着重要作用［1-2］。人类尼尔样-1型分子（Nel-like molecule-1, NELL-1）基因位于第11号染色体p15.1p15.2，长度约906 kb，包含20个编码外显子。基因编码的分泌蛋白包含810个氨基酸开放阅读框架，其相对分子质量在糖基化之前约为90 ...
Whey protein, amino acids, and vitamin D supplementation with physical activity increases fat-free mass and strength, functionality, and quality of life and decreases inflammation in sarcopenic elderly
amino acids dietary supplement elderly insulin-like growth factor I fat-free mass relative skeletal muscle mass sarcopenia vitamin D whey protein
2018/11/28
Background: Interventions to attenuate the adverse effects of age-related loss of skeletal muscle and function include increased physical activity and nutritional supplementation.