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合肥工业大学食品与生物工程学院在细胞穿梭的合成泛素探针研究领域取得新进展（图）
合肥工业大学食品与生物工程学院 细胞穿梭 合成泛素探针 Angewandte Chemie International Edition 蛋白质
2023/1/8
近日，合肥工业大学食品与生物工程学院李宜明教授课题组在细胞穿梭、时间分辨的合成泛素探针工具研究领域取得新进展。相关研究成果“Photocaging of Activity-based Ubiquitin Probes via a C-Terminal Backbone Modification Strategy”在国际知名化学期刊《Angewandte Chemie International E...
线粒体中实现A到G碱基转换 基因编辑技术，最后一块拼图补齐
线粒体 碱基转换 细胞 基因编辑
2022/5/10
韩国基础科学研究所（IBS）基因组工程中心研究人员开发了一种新的基因编辑平台，称为类转录激活因子效应相关脱氨酶（TALED）。TALED是能够在线粒体中进行A到G碱基转换的碱基编辑器。这一发现是长达数十年治愈人类遗传疾病之旅的结晶，而TALED，也被认为是基因编辑技术中最后缺失的一块拼图。研究成果发表在最新一期《细胞》杂志上。
In human chromosomes, DNA is coated by proteins to form an exceedingly long beaded string. This “string” is folded into numerous loops, which are believed to help cells control gene expression and fac...
Despite the sheer number of genes that each human cell contains, these so-called “coding” DNA sequences comprise just 1 percent of our entire genome. The remaining 99 percent is made up of “non-coding...
MIT chemists have discovered the structure of a protein that can pump toxic molecules out of bacterial cells. Proteins similar to this one, which is found in E. coli, are believed to help bacteria bec...
Ateam of researchers led by Harvard and Broad Institute scientists has developed a new drug-delivery system using engineered DNA-free virus-like particles (eVLPs) that is able to edit genes associated...
Despite its minute size, a single cell contains billions of molecules that bustle around and bind to one another, carrying out vital functions. The human genome encodes about 20,000 proteins, most of ...
In Down syndrome cells, genome-wide disruptions mimic a senescence-like state（图）
唐氏综合症 细胞生物学 全基因组 破坏模仿 衰老样状态
2023/6/6
In Down syndrome, the third copy of chromosome 21 causes a reorganization of the 3D configuration of the entire genome in a key cell type of the developing brain, a new study shows. The resulting disr...
Ateam of researchers led by Harvard and Broad Institute scientists has developed twin prime editing, a new, CRISPR-based gene-editing strategy that enables manipulation of gene-sized chunks of DNA in ...
The versatility of the nervous system comes from not only the diversity of ways in which neurons communicate in circuits, but also their “plasticity,” or ability to change those connections when new i...
Achewing gum laced with a plant-grown protein serves as a “trap” for the SARS-CoV-2 virus, reducing viral load in saliva and potentially tamping down transmission, according to a new study.
Cut off the head of a three-banded panther worm, and it will grow another — mouth, brain, and all. Cut off its tail, and the same thing happens. Cut it in three pieces, and within eight weeks there’ll...
When Sharif Tabebordbar was a teenager, his father began having trouble walking. Soon, he became wheelchair-bound and was diagnosed with a rare genetic muscle disease.
The cost of DNA sequencing has plummeted at a rate faster than Moore’s Law, opening large markets in the sequencing space. Genomics for cancer care alone is predicted to hit $23 billion by 2025, but s...
