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Researchers at MIT and Harvard University have designed a way to selectively turn on gene therapies in target cells, including human cells. Their technology can detect specific messenger RNA sequences...
Infections caused by fungi, such as Candida albicans, pose a significant global health risk due to their resistance to existing treatments, so much so that the World Health Organization has highlighte...
眼睛中的光感受器退化是导致视力下降的主要原因之一,最终可能导致失明,目前尚无有效治疗方法。近期,杜克-新加坡国立大学医学院与卡罗林斯卡学院等机构的研究人员开发了一种新方法,能够促进人类胚胎干细胞(hESCs)分化为感光祖细胞,将这些细胞移植到实验模型中可以部分恢复视网膜功能。研究成果发表在《Molecular Therapy》期刊,标题为“Photoreceptor laminin drives ...
Inspired by sutures developed thousands of years ago, MIT engineers have designed “smart” sutures that can not only hold tissue in place, but also detect inflammation and release drugs.
Anew genetic variant that protects against Alzheimer’s disease has been identified by an international team led by Harvard Medical School investigators at Massachusetts General Hospital and Massachuse...
瑞典卡罗林斯卡医学院国家生命科学实验室开发了一种新的研究工具——InParanoiDB9,旨在增进对不同生物体之间蛋白质同源关系的理解。它预测了640个物种之间超10亿个直向同源群,为蛋白质结构域和全长蛋白质提供了直向同源预测。
Genomic studies of cancer patients have revealed thousands of mutations linked to tumor development. However, for the vast majority of those mutations, researchers are unsure of how they contribute to...
A new method for analyzing protein crystals – developed by Cornell researchers and given a funky two-part name – could open up applications for new drug discovery and other areas of biotechnology and ...
According to MIT’s charter, established in 1861, part of the Institute’s mission is to advance the “development and practical application of science in connection with arts, agriculture, manufactures,...
Much of the human genome is made of regulatory regions that control which genes are expressed at a given time within a cell. Those regulatory elements can be located near a target gene or up to 2 mill...
MIT researchers are using artificial intelligence to design new proteins that go beyond those found in nature.
Engineers at MIT and the University of Massachusetts Medical School have designed a new type of nanoparticle that can be administered to the lungs, where it can deliver messenger RNA encoding useful p...
One of the most expensive steps in manufacturing protein drugs such as antibodies or insulin is the purification step: isolating the protein from the bioreactor used to produce it. This step can accou...
为在原子水平上了解光合作用过程,波兰雅盖隆大学科研人员对一种关键光合蛋白进行了研究,发现了细胞色素b6f蛋白复合物的高分辨率冷冻电镜结构。
人三磷酸腺苷(ATP)依赖的核糖核酸(RNA)解旋酶A(DHX9)是一种多功能核蛋白,广泛参与RNA的加工、转录和翻译。研究表明,DHX9可以与细胞核中的亚基结合,促进下游促炎细胞因子转录,抵抗脱氧核糖核酸(DNA)病毒感染,且多种病毒劫持DHX9以逃避先天免疫系统并促进自我复制。但是,DHX9能否在调节细胞核中针对RNA病毒的先天免疫发挥作用尚不清楚。近日,中国科学技术大学、广州医科大学和耶鲁大...

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