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Functional Insights Into Oncogenic Protein Tyrosine Phosphatases By Mass Spectrometry
Protein Tyrosine Phosphatases Mass Spectrometry
2015/5/25
Phosphatase of Regenerating Liver 3 (PRL3) is suspected to be a causative factor toward cellular metastasis when overexpressed. To date, the molecular basis for PRL3 function remains an enigma, justif...
Expression and Function of the PRL Family of Protein Tyrosine Phosphatase
PRL phosphatase PTP4A DSP cancer
2015/5/22
The PRL family of enzymes constitutes a unique class of protein tyrosine phosphatase, consisting of three highly homologous members (PRL-1, PRL-2, and PRL-3). Family member PRL-3 is highly expressed i...
Effects of Ca2+ and HCO3- on Capacitation, Hyperactivation and Protein Tyrosine Phosphorylation in Guinea Pig Spermatozoa
Capacitation Hyperactivation Tyrosine Phosphorylation Sperm
2016/4/29
In our previous report, we demonstrated that the tyrosine phosphorylation of sperm proteins (TPSP) of guinea pig was associated with capacitation and hyperactivation (CAHA), and Ca2+ and HCO3- were re...
As a therapeutic target, protein tyrosine phosphatase 1B (PTP1B) has received considerable attention for the treatment of diabetes mellitus. A QSAR study using substituted monocyclic and polycyclic th...
Regulation of sperm function by protein tyrosine phosphorylation in diverse wild felid species
Cat cAMP capacitation
2009/2/18
Protein tyrosine phosphorylation is associated with sperm capacitation and the acrosome reaction in several mammalian species. Changes in phosphorylation of a 95-kDa protein in human, mouse, and d...
Specific Order in the Appearance of Protein Tyrosine Phosphorylation Patterns Is Functionally Coordinated With Dog Sperm Hyperactivation and Capacitation
Kinetics hyperactivation membrane destabilization sperm function phosphorylation
2008/12/19
The aims of the present study were to characterize a slow capacitation system that records initial changes in the sperm membrane state, and, using a canine model, to order the specific protein tyros...
Capacitation-associated Changes in Protein-tyrosine-phosphorylation, Hyperactivation and Acrosome Reaction in Guinea Pig Sperm
Acrosome Reaction Capacitation Hyperactivation Tyrosine Phosphorylation Semen
2016/4/27
The aim of this study was to evaluate the effects of Ca2+, HCO3- and BSA on the in vitro capacitation-associated protein tyrosine phosphorylation, hyperactivation and acrosome reaction in guinea pig s...
Overexpression of Protein Tyrosine Phosphatase 1B in HepG2 Cells Ameliorates Insulin-mediated Suppression of Apolipoprotein B mRNA Translation Via Its Untranslated Regions
Protein tyrosine phosphatase 1B Untranslated region In vitro translation assay
2010/4/19
Background: The hepatic secretion of apolipoprotein B (apoB), containing lipoproteins, is known to be regulated by insulin, and the overproduction of these atherogenic lipoproteins occurs in insulin-r...