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近日,合成生物学领域国际知名期刊《代谢工程》(Metabolic Engineering)在线发表了武汉大学药学院、中南医院药学研究院、泰康生命医学研究中心邓子新院士团队陈文青教授课题组关于“搭建大肠杆菌平台,智造核苷类医药中间体”的重要研究成果。武汉大学为该论文的第一署名单位,博士研究生于乐、高耀杰为共同第一作者,陈文青教授为通讯作者。
Metabolic engineering in woody plants: challenges, advances, and opportunities
Woody plant Metabolic engineering Bioeconomy Sustainability
2023/12/5
Woody plant species represent an invaluable reserve of biochemical diversity to which metabolic engineering can be applied to satisfy the need for commodity and specialty chemicals, pharmaceuticals, a...
Two environmental signal-driven RNA metabolic processes: alternative splicing and translation
alternative splicing environmental signal receptor kinase RNA metabolism
2023/11/16
Plants live in fixed locations and have evolved adaptation mechanisms that integrate multiple responses to various environmental signals. Among the different components of these response pathways, rec...
OsPP65 Negatively Regulates Osmotic and Salt Stress Responses Through Regulating Phytohormone and Raffinose Family Oligosaccharide Metabolic Pathways in Rice
PP2C Osmotic stress tolerance ABA JA Raffinose family oligosaccharide Rice
2023/4/21
Dietary compounds regulating the mammal peripheral circadian rhythms and modulating metabolic outcomes
哺乳动物 昼夜节律 调节代谢 膳食化合物
2023/4/19
The circadian rhythm regulates the daily cycles of various physiological activities. Accumulating evidences revealed that circadian rhythm plays an important role in regulating metabolic homeostasis, ...
Molecular Basis of the Distinct Metabolic Features in Shoot Tips and Roots of Tea Plants (Camellia sinensis): Characterization of MYB Regulator for Root Theanine Synthesis
alternative splicing full-length transcriptome catechins noncoding RNA transcription factor theanine synthesis
2023/4/20
The physiological and metabolic difffferences between shoot tips and roots of tea plants are signifificant, and understanding them is required for improvement of tea quality and plant growth. A high-q...
高效的代谢途径是细胞工厂生产的关键,然而同源或异源多基因途径的不平衡和低效,会导致潜在的有毒中间体的积累。CRISPR技术可以提供更加简单、高效、低成本的代谢途径改造与优化方法。 中科院天津工业生物技术研究所张学礼研究员带领的微生物代谢工程团队和毕昌昊研究员带领的合成生物技术研究团队,受邀在Metabolic Engineering发表基于CRISPR的代谢工程调控前沿综述。该文章介绍了传统的代谢...
Flipping a metabolic switch to slow tumor growth(图)
Flipping metabolic switch tumor growth
2020/8/27
An enzyme can be used as a metabolically responsive "switch" that decreases tumor growth, according to a new study. The findings are published in the journal Nature.By restricting the dietary ami...
No metabolic effects of mustard allyl-isothiocyanate compared with placebo in men
mustard allyl-isothiocyanate energy expenditure thermogenesis thermogenic food
2018/11/20
Background: Induction of nonshivering thermogenesis can be used to influence energy balance to prevent or even treat obesity. The pungent component of mustard, allyl-isothiocyanate (AITC), activates t...
中国地质大学科学技术发展院李平BGEG国家重点实验室 WATER RES,2017. Analysis of the functional gene structure and metabolic potential of microbial community in high arsenic groundwater
高砷;地下水;微生物;功能结构;代谢;潜能;分析
2021/10/21
近日,中国地质大学生物地质与环境地质国家重点实验室李平团队在国际著名期刊《Water Research》(IF 6.942)上在线发表了论文——高砷地下水中微生物群落功能结构及其代谢潜能分析(Analysis of the functional gene structure and metabolic potential of microbial community in high arsenic...
Investigating predictors of eating: is resting metabolic rate really the strongest proxy of energy intake?
appetite eating behavior traits energy intake error variance resting metabolic rate
2018/11/20
Background: Evidence suggests that fat-free mass and resting metabolic rate (RMR), but not fat mass, are strong predictors of energy intake (EI). However, body composition and RMR do not explain the e...
The use of metabolic balance studies in the objective discrimination between intestinal insufficiency and intestinal failure
intestinal absorption intestinal malabsorption intestinal
2018/11/19
Background: In research settings that use metabolic balance studies (MBSs) of stable adult patients with short bowel syndrome, intestinal failure (IF) and dependence on parenteral support (PS) have be...
The use of metabolic balance studies in the objective discrimination between intestinal insufficiency and intestinal failure
intestinal absorption intestinal malabsorption intestinal
2018/11/16
Background: In research settings that use metabolic balance studies (MBSs) of stable adult patients with short bowel syndrome, intestinal failure (IF) and dependence on parenteral support (PS) have be...
Maternal protein intake in pregnancy and offspring metabolic health at age 9–16 y: results from a Danish cohort of gestational diabetes mellitus pregnancies and controls
pregnancy gestational diabetes mellitus protein insulin body composition
2018/11/15
Background: Recent years have seen strong tendencies toward high-protein diets. However, the implications of higher protein intake, especially during developmentally sensitive periods, are poorly unde...