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Brassinosteroid-Activated BRI1-EMS-SUPPRESSOR 1 Inhibits Flavonoid Biosynthesis and Coordinates Growth and UV-B Stress Responses in Plants
UV-B light BES1 brassinosteroids flavonoids
2023/12/21
Ultraviolet B (UV-B) light is a potential stress factor in plants, but how plants coordinate growth and UV-B stress responses is not well understood. Here we report that brassinosteroid (BR) signaling...
Gossypol Broadly Inhibits Coronaviruses by Targeting RNA-Dependent RNA Polymerases
棉花 次生代谢物 棉酚 抑制冠状病毒
2024/4/16
研究团队以SARS-CoV-2为实验模型，采用计算机高通量筛选、酶学验证、抗病毒实验和冷冻电镜表征等多学科交叉的方式，从棉花中筛选到一种重要的次生代谢物——棉酚，发现棉酚能够广谱抑制冠状病毒。研究结果开辟了多学科交叉和多元化利用新方向，对促进棉花天然产物的研究和利用、拓宽棉花副产品的价值链具有重要意义。
Protein ingestion acutely inhibits insulin-stimulated muscle carnitine uptake in healthy young men
doubly labeled water energy requirement resting energy expenditure short bowel syndrome total energy expenditure
2018/11/26
Background: Increasing skeletal muscle carnitine content represents an appealing intervention in conditions of perturbed lipid metabolism such as obesity and type 2 diabetes but requires chronic L-car...
Rapamycin Inhibits Expression of Elongation of Very-long-chain Fatty Acids 1 and Synthesis of Docosahexaenoic Acid in Bovine Mammary Epithelial Cells
Bovine Mammary Epithelial Cells Mammalian Target of Rapamycin Complex
2016/11/10
Mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of cell growth and metabolism and is sufficient to induce specific metabolic processes, including de novo lipid biosynthesis. El...
A novel aromatic oil compound inhibits microbial overgrowth on feet: a case study
feet inhibits microbial overgrowth
2015/7/8
Athlete's Foot (Tinea pedis) is a form of ringworm associated with highly contagious
yeast-fungi colonies, although they look like bacteria. Foot bacteria overgrowth produces a
harmless pungent odor...
Lactoferrin inhibits E. coli O157:H7 growth and attachment to intestinal epithelial cells
transferring type III secretion system EspA
2015/4/7
Enterohemorrhagic Escherichia coli (EHEC) serotype O157:H7 strains are associated with haemorraghic colitis and haemolytic uremic syndrome (HUS) in humans. Cattle are a reservoir of E. coli O157:H7. W...
Bean Polygalacturonase-inhibiting Protein Expressed in Transgenic Brassica napus Inhibits Polygalacturonase from its Fungal Pathogen Rhizoctonia solani
canola bean transformation PGIP
2015/3/9
Polygalacturonase-inhibiting proteins (PGIPs) selectively inhibit polygalacturonases (PGs) secreted by invading plant pathogenic fungi. The objective of present research was to clone and introduce the...
Triptolide Directly Inhibits dCTP Pyrophosphatase
Pyrophosphatase Triptolide Directly Inhibits
2014/11/25
Triptolide is a potent natural product, with documented antiproliferative, immunosuppressive, anti-inflammatory, antifertility, and antipolycystic kidney disease effects. Despite a wealth of knowledge...
Decreased Autocrine EGFR Signaling in Metastatic Breast Cancer Cells Inhibits Tumor Growth in Bone and Mammary Fat Pad
autocrine signaling bone marrow cells breast cancer
2014/11/6
Breast cancer metastasis to bone triggers a vicious cycle of tumor growth linked to osteolysis. Breast cancer cells and osteoblasts express the epidermal growth factor receptor (EGFR) and produce ErbB...
Protein extract of tobacco expressing StoVe1 gene inhibits Verticillium dahliae proliferation
disease resistance regeneration StoVe1 transformation tobacco
2014/2/24
Verticillium dahliae is a principal pathogen causing verticillium wilt in Solanaceae crops. StoVe1 is a gene resisting to verticillium wilt isolated from Solanum torvum. In order to generate resistant...
Thymoquinone Suppresses Cellular Proliferation, Inhibits VEGF Production and Obstructs Tumor Progression and Invasion in the Rat Model of DMH-Induced Colon Carcinogenesis
Thymoquinone PCNA-LI VEGF Serum Levels
2013/2/19
A myriad of medicinal effects has been attributed to Thymoquinone (TQ), the major biological-active component of Nigella sativa. TQ has been shown to exhibit potent anti-tumor activities. The present ...
Growth and differentiation factor-11 is developmentally regulated in skeletal muscle and inhibits myoblast differentiation
GDF-11 Developmental Expression Post-Natal Muscle Growth Sexual Dimorphism Myoblast Differentiation
2013/1/30
Growth and differentiation factor-11 (GDF-11) is a secreted protein that is closely related to myostatin, a known inhibitor of skeletal muscle development. The role of GDF-11 in regulating skeletal mu...
Diclofenac inhibits Kv1.3 and Kir2.1 expressions in human macrophages and affects the membrane potential and foam cell formation
离子通道 膜电位 巨噬细胞 双氯酚酸 细胞分化
2012/8/20
目的分研究双氯芬酸对人巨噬细胞电压依赖性钾通道Kv1.3、内向整流钾通道Kir2.1表达的影响及意义。方法以健康人外周血单核细胞源性巨噬细胞对象，采用Real-time RT-PCR及Western blot技术研究双氯芬酸对Kv1.3和Kir2.1表达的影响；电压敏感染料膜电位标测技术分析膜电位的变化，并用酶荧光化学法检测摄取氧化修饰低密度脂蛋白（OxLDL）的巨噬细胞内胆固醇酯（CE）的构成比...
Publication in Neuropsychopharmacology Confirms CeNeRx's Novel RIMA Antidepressant TriRima™ Selectively and Reversibly Inhibits MAO-A
Neuropsychopharmacology Confirms MAO-A CeNeRx's Novel RIMA Antidepressant TriRima&trade
2009/12/16
CeNeRx BioPharma, Inc., a clinical stage company developing innovative treatments for diseases of the central nervous system, today announced that a newly published PET imaging study in human subjects...
Electrolyzed-reduced water inhibits acute ethanol-induced hangovers in Sprague-Dawley rats
Electrolyzed-reduced ethanol-induced
2009/12/16
Ethanol consumption disturbs the balance between the pro- and anti-oxidant systems of the organism, leading to oxidative stress. Electrolyzed-reduced water (ERW) is widely used by people in East Asia ...