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Knockout of Myostatin by Zinc-finger Nuclease in Sheep Fibroblasts and Embryos
Myostatin Zinc-finger Nucleases Knockout, Sheep
2016/11/10
Myostatin (MSTN) can negatively regulate the growth and development of skeletal muscle, and natural mutations can cause “double-muscling” trait in animals. In order to block the inhibiting effect of M...
Generation of Fibroblasts Lacking the Sal-like 1 Gene by Using Transcription Activator-like Effector Nuclease-mediated Homologous Recombination
Transcription Activator-like Effector Nuclease [TALEN] Sal-like 1 Gene
2016/5/20
The Sal-like 1 gene (Sall1) is essential for kidney development, and mutations in this gene result in abnormalities in the kidneys. Mice lacking Sall1 show agenesis or severe dysgenesis of the kidneys...
Knock-in of Enhanced Green Fluorescent Protein or/and Human Fibroblast Growth Factor 2 Gene into β-Casein Gene Locus in the Porcine Fibroblasts to Produce Therapeutic Protein
Knock-in Homologous Recombination Therapeutic Proteins Porcine β-casein Gene
2016/5/17
Transgenic animals have become important tools for the production of therapeutic proteins in the domestic animal. Production efficiencies of transgenic animals by conventional methods as microinjectio...
Modulation of peroxisomes abundance by argan oil and lipopolysaccharides in acyl-CoA oxidase 1-deficient fibroblasts
Acyl-CoA Oxidase 1 Argan Oil LPS PGC-1a Peroxisome Proliferation P-NALD PPARa
2013/1/29
Pseudo-neonatal adrenoleukodystrophy (P-NALD) is a neurodegenerative disorder caused by acyl-CoA oxidase 1 (ACOX1) deficiency with subsequent impairment of peroxisomal fatty acid β-oxidation, accumula...
Interactions between sub-10 nm iron and cerium oxide nanoparticles and 3T3 fibroblasts : the role of the coating and aggregation state
Nanoparticle Magnetism Cell proliferation Cell viability Fibroblast Polyacrylic acid
2010/11/19
Recent nanotoxicity studies revealed that the physico-chemical characteristics of engineered nanomaterials play an important role in the interactions with living cells. Here, we report on the toxicity...
Knocking-in of the Human Thrombopoietin Gene on Beta-casein Locus in Bovine Fibroblasts
Animal Bioreactor Bovine Beta-casein Gene Knock-in Human Thrombopoietin (hTPO) Gene Bovine Fibroblasts Somatic Cell Nuclear Transfer (SCNT)
2016/5/5
Animal bioreactors have been regarded as alternative tools for the production of limited human therapeutic proteins. The mammary glands of cattle are optimal tissues to produce therapeutic proteins th...
Influence of nanofibers on growth and gene expression of human tendon derived fibroblasts
nanofibers growth and gene expression human tendon fibroblasts
2010/2/25
This study indicates that the use of nanofibers influence expression of genes associated with the extra cellular matrix formation. The composition of the nanofibers plays a critical role. While PLLA/C...
Effects of high-dose major components in oral disinfectants on the cell cycle and apoptosis in primary human gingival fibroblasts in vitro
Cell cycle and apoptosis Human gingival fibroblasts Oral disinfectants
2010/11/26
We evaluated the effects of high-dose major components in oral disinfectants on oral cells from the standpoints of the cell cycle and apoptosis. We examined the viability and cell cycle of human gingi...
Corneal and Conjunctival Fibroblasts Are Major Sources of Eosinophil-Recruiting Chemokines
chemokine conjunctiva epithelial cells fibroblast gene expression
2010/11/16
Corneal and conjunctival fibroblasts exhibited marked increases in the expression of chemokines upon stimulation with TNF-α and IL-4, suggesting that fibroblasts may be one of the primary sources of c...
Evaluation of fibronectin,type I collagen and TGF-ß expression by human periodontal ligament fibroblasts exposed to root end filling materials
Evaluation fibronectin type collagen TGF-ß expression human periodontal ligament fibroblasts filling materials
2009/12/7
Background and Aim: Several materials have been introduced for retrograde fillings, pulp capping and sealing root perforations, but their biological effect on vital tissues and cells is not clear. The...
Influence of Novel Resin Monomer on Viability of L-929 Mouse Fibroblasts in vitro
Monomer Cell viability Methyl methacrylate
2009/9/15
We have previously synthesized a novel acrylic resin monomer, methacryloyloxyethyl methyl succinate (TA). The aim of this in vitro study, therefore, was to examine its influence on cell viability usin...
Analysis of the Cytotoxicity of Four Dentin Bonding Agents on Gingival Fibroblasts
Dentin bonding agents gingival fibroblasts MTT cell culture
2009/6/22
The objective of this study is to evaluate effects of four dentin bonding agents PromptL-Pop, Syntac, Pekabond, Scotchbond-1 on cell proliferation in human gingival fibroblast cultures. Under aseptic ...
Effects of hyperbaric oxygen and platelet derived growth factor on medial collateral ligament fibroblasts
Hyperbaric Oxygenation collagen collagen fibrils platelet-derived growth factor-BB platelet medial collateral ligament fibroblast animal rabbit
2009/6/2
This study investigated hyperbaric oxygen (HBO2) and platelet-derived growth factor-BB (PDGF-BB) to determine their combined effects on fibroblasts from rabbit medial collateral ligament (MCL). METHOD...
Influence of Intermittent Hyperoxia on Hypoxic Fibroblasts
Intermittent Hyperoxia Hypoxic Fibroblasts
2009/5/8
Anderson LH, Wilson B, Herring RF, Mehm WJ. Influence of Intermittent Hyperoxia on Hypoxic Fibroblasts. J. Hyperbaric Med 1992; 7(2):103-114.
Influence of cigarette smoke and nicotine on the morphological change of human periodontal ligament fibroblasts
cigarette smoke nicotine free radical HPLF inflammatory cytokine
2009/5/6
Cigarette smoking is a risk factor for periodontal disease. The effect of cigarette smoke and nicotine, a major component of tobacco, on the morphological changes of human periodontal ligament fibrobl...