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Gossypol Broadly Inhibits Coronaviruses by Targeting RNA-Dependent RNA Polymerases
棉花 次生代谢物 棉酚 抑制冠状病毒
2024/4/16
研究团队以SARS-CoV-2为实验模型，采用计算机高通量筛选、酶学验证、抗病毒实验和冷冻电镜表征等多学科交叉的方式，从棉花中筛选到一种重要的次生代谢物——棉酚，发现棉酚能够广谱抑制冠状病毒。研究结果开辟了多学科交叉和多元化利用新方向，对促进棉花天然产物的研究和利用、拓宽棉花副产品的价值链具有重要意义。
Researchers uncover clues about how HIV virus mutates away from broadly neutralizing antibody
Researchers HIV virus mutates away broadly neutralizing antibody
2017/7/21
A new study published in Cell Host & Microbe led by researchers at Fred Hutchinson Cancer Research Center completely maps all mutations that help the HIV virus evolve away from a single broadly neutra...
In an effort to better promote discovery science and engineering to a wider range of audiences, the National Science Foundation (NSF) has launched three new multimedia communications vehicles: a video...
Challenges on Induction of Broadly Neutralizing Antibodies for Optimization of HIV Vaccines Development and Vectored Immunoprophylaxis
HIV AIDS Broadly Neutralizing Antibodies (bNAbs) Vectored Immunoprophylaxis
2013/1/30
Despite extensive research efforts, a preventive human immunodeficiency virus (HIV) vaccine remains one of the major challenges in the field of AIDS research. Experimental strategies which have been p...