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中国科学院动物研究所专利：Fusion protein for inducing pluripotent stem cells and application method thereof
中国科学院动物研究所 专利 哺乳动物 YAP蛋白 转录控制活性
2024/5/31
提供了由哺乳动物YAP蛋白或具有转录控制活性的片段的融合蛋白的与细胞全能性和转录激活结构域相关的基因编码的蛋白、编码核苷酸序列、表达载体及其组合物，以及使用该融合蛋白诱导多能干细胞的方法。
中国科学院动物研究所专利：Delayed senescence, malignant conversion of human mesenchymal stem cells can be a resistor, its preparation and use
中国科学院动物研究所 专利 人骨髓间 充质干细胞
2024/5/30
延缓衰老，制备恶性人骨髓间充质干细胞的方法可抗选择性。 制备方法， 第二密码子的253个氨基酸残基的FOXO3蛋白， 丝氨酸密码子编码丙氨酸突变的密码子，FOXO3蛋白密码子的第315位氨基酸残基，丝氨酸密码子编码丙氨酸突变的密码子编码2个突变中的一个突变，编码多能干细胞的基因组包括该步骤。 制备的重组间充质干细胞，并进一步提供其在移植治疗中的用途。 [附图]
Simultaneous expansion and harvest of hematopoietic stem cells and mesenchymal stem cells derived from umbilical cord blood
生物反应器 UCB MSCs RWV GCSC
2023/3/1
The simultaneous expansion and harvest of hematopoietic stem cells and mesenchymal stem cells derived from umbilical cord blood were carried out using bioreactors. The co-culture of umbilical cord blo...
脊髓损伤(Spinal Cord Injury, SCI)引起的原发性和继发性白质损伤会导致长期的运动功能缺陷，通过在受损的轴突和目标神经元之间插入新的神经元可以实现功能连接的重建，神经干细胞(Neural Stem Cells, NSCs)有望在脊髓损伤断端之间重建通信。然而，SCI后形成的抑制性微环境往往导致内源性和移植的NSCs向胶质细胞而不是神经元分化。已有研究表明，功能生物材料可减轻SC...
2019年11月13日，浙江大学医学院附属口腔医院王慧明教授团队在STEM CELLs（干细胞领域权威期刊之一）上在线发表题为“KLF2+ stemness maintains human mesenchymal stem cells in bone regeneration”的研究论文，首次提出采用KLF2作为人骨髓间充质干细胞(hMSCs)体外标志物，并研究KLF2+hMSCs在血管再生和骨组...
NSF-funded researchers have created better biosensor technology using a newly developed instrument that may lead to safe stem cell therapies for treating Alzheimer's and Parkinson's diseases and other...
FASE刊“Large Animal Stem Cells”专辑综述文章全面阐述猪多能性干细胞最新研究进展及科学展望（图）
FASE刊 Large Animal Stem Cells 综述文章 猪 多能性干细胞 动物育种应用
2019/3/12
多能干细胞（PSC）因其具有自我更新和多向分化潜能，在体外可以长期培养并能进行基因编辑，其在生命科学与医学领域，以及动物育种应用等领域备受青睐。然而，大家畜，如猪，至今没有获得能够进行生殖嵌合、稳定传代、体外长期培养的多能干细胞系。这也是制约大家畜育种的瓶颈。自第一株小鼠胚胎干细胞报道以来，科学家对猪多能干细胞进了30多年的攻关，虽取得了良好的进展，但仍存在急需解决的科学问题。近日，由中国农业大学...
加州大学圣地亚哥分校医学院的研究人员在当前在线期刊《Stem Cells and Development》杂志上撰文，描述了一种快速，经济有效的从原代细胞中制造人皮层类器官的方法。
2017冷泉港亚洲会议：干细胞，老化和复兴（Cold Spring Harbor Asia conference on Stem Cells,Aging&Rejuvenation ）
2017 冷泉港亚洲 会议 干细胞 老化 复兴
2017/2/13
We are pleased to announce the 1st Cold Spring Harbor Asia conference on Ubiquitin Family, Autophagy and Diseases which will be held in Suzhou, China, located approximately 60 miles west of Shanghai. ...
Stem Cells Step Forward
Stem Cells Step Forward
2017/3/13
Researchers at Harvard Medical School and Boston Children’s Hospital were able, for the first time, to use patients’ own cells to create cells similar to those in bone marrow and then use them to iden...
The sixth Gordon Conference on Stem Cells and Cancer will focus on how stem cell aging influences the initiation and progression of cancer. Aging leads to progressive impairments in stem cell function...
Researchers use stem cells to regenerate the external layer of a human heart
Researchers stem cells regenerate the external layer human heart
2017/2/16
A process using human stem cells can generate the cells that cover the external surface of a human heart — epicardium cells — according to a multidisciplinary team of researchers."In 2012, we discover...
Gordon Research Conference on Tissue Niches & Resident Stem Cells in Adult Epithelia
Tissue Niches Resident Stem Cells
2016/7/29
Adult epithelia regenerate during adult life due to the constant activity of stem cell pools. Stem cells maintain tissue homeostasis and repair injury by close communication with their tissue environm...
Prenatal Maternal Physical Activity and Stem Cells in Umbilical Cord Blood
REAST STEM CELLS CARDIOVASCULAR FITNESS EARLY LIFE DETERMINANTS
2017/4/13
Purpose: Early life processes, through influence on fetal stem cells, affect postnatal and adult health outcomes. This study examines the effects of physical activity before and during pregnancy on st...
Effects of Extracellular Matrix Protein-derived Signaling on the Maintenance of the Undifferentiated State of Spermatogonial Stem Cells from Porcine Neonatal Testis
Porcine Spermatogonial Stem Cells Undifferentiation, Extracellular Matrix Proteins
2016/11/10
In general, the seminiferous tubule basement membrane (STBM), comprising laminin, collagen IV, perlecan, and entactin, plays an important role in self-renewal and spermatogenesis of spermatogonial ste...