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A fertilized human egg develops into multiple tissues, organs and about 200 distinct cell types. Each cell type has the same genes, but they are expressed differently during development and in mature ...
Low Levels of p53 Protein and Chromatin Silencing of p53 Target Genes Repress Apoptosis in Drosophila Endocycling Cells
apoptosis endocycling cells p53 protein
2015/1/7
Apoptotic cell death is an important response to genotoxic stress that prevents oncogenesis. It is known that tissues can differ in their apoptotic response, but molecular mechanisms are little unders...
CD4 Silencing in Thmocytes is Opposed by the Enforced Association of P300 HAT, HDAC1 or SUV39H1 with Runx Transcription Factors
CD4 Silencing in Thymocytes the Enforced Association P300 HAT HDAC1 SUV39H1 Runx Transcription Factors
2014/10/23
CD4 Silencing in Thmocytes is Opposed by the Enforced Association of P300 HAT, HDAC1 or SUV39H1 with Runx Transcription Factors.
Validation of Gene Silencing Using RNA Interference in Buffalo Granulosa Cells
RNAi Transfection CYP19 Gene 17beta- Estradiol Buffalo Transcript Abundance
2016/5/9
Silencing of a specific gene using RNAi (RNA interference) is a valuable tool for functional analysis of a target gene. However, information on RNAi for analysis of gene function in farm animals is re...
Giving epilepsy patients an electric jolt to shut off out-of-control neuron firing during seizures is being explored as a way to treat the chronic brain disorder. New research from MIT now raises the ...
Silencing Ophelia: Male Aurality as a Controlling Element in Olivier's Hamlet
Silencing Ophelia Male Aurality
2009/12/4
In nearly all cinematic adaptations of Hamlet, Ophelia's role is the one most radically reduced by directors: her soliloquy is frequently excised, her remaining lines are abbreviated, her appearances ...
Writing, Erasing, Silencing: Tina Blau and the (Woman) Artist's Biography（图）
Writing Erasing Silencing Tina Blau the (Woman) Artist's Biography
2009/11/20
A canon, in art history, is a virtual museum of works deemed worth remembering. But the canon's very existence depends upon silencing the things on its periphery. Any center, as historian Joan Scott r...
Use of RNA interference technology for cancer specific gene silencing
RNA interference siRNA cancer gene therapy
2009/7/15
RNA interference (RNAi) can be applied to human cancer cells by using small interfering RNAs (siRNAs) for inhibition of activated oncogenes' expression with the amelioration of several malignant pheno...
One step closer to turning off cancer genes with gene-silencing
cancer genes gene-silencing one step
2009/6/5
Researchers at The University of Queensland have developed a way to deliver drugs which can specifically shut down cancer-causing genes in tumour cells while sparing normal healthy tissues.
JOURNAL OF RNAi AND Gene Silencing（图）
JOURNAL OF RNAi AND Gene Silencing RNA interference gene silencing gene targeting research 基因
2008/1/16
The Journal will publish high-quality peer-reviewed articles addressing the biology and application of RNA interference and gene silencing in all systems. The Journal aims at providing an efficient ro...
组蛋白去乙酰化酶SIR2与染色质沉默The Histone Deacetylase Activity of SIR2 and Chromatin Silencing
组蛋白去乙酰化酶 SIR2 染色质沉默 组蛋白乙酰转移酶 NAD
2007/12/31
摘要DNA的大部分区域通过包装成特殊的染色质结构而失去活性称为染色质沉默。这些特殊的染色质结构在维持染色体结构稳定和基因调控中起重要作用。有实验表明，沉默染色质的组蛋白H3和H4的的氨基末端尾部相对于基因组的其他区域是低乙酰化的。组蛋白去乙酰化酶SIR2（silent information regulator2）是参与染色质沉默的一种重要的蛋白质。SIR2具有两种相关联的酶活性，组蛋白去乙酰化酶...
RNA介导的转基因沉默:原理及应用RNA-based Transgene Silencing:Mechanism and Applications
转录后基因沉默(PTGS) 双链RNA(ds RNA) RNA指导的DNA甲基化(RdDM)
2007/12/31
摘要RNA介导的转基因沉默是有dsRNA参与指导的,以外源和内源mRNA为降解目标的转基因沉默现象。本文对植物中RNA介导的转基因沉默的机理做了详细的阐述,并且将各种生物中在此过程中起关键作用的蛋白及其功能进行了总结，最后介绍dsRNA作为一种基因组学研究手段的优势和它实际的应用前景。
Abstract:RNA-based transgene silencing is a phenomenon ...