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Discovery of novel regulators of aldehyde dehydrogenase isoenzymes
ALDH2 Characterization High-throughput docking approach
2015/5/25
Recent work has shown that specific ALDH isoenzymes can contribute to the underlying pathology of different diseases. Many ALDH isozymes are important in oxidizing reactive aldehydes resulting from li...
Identification, kinetic and structural characterization of small molecule inhibitors of aldehyde dehydrogenase 3a1 (Aldh3a1) as an adjuvant therapy for reversing cancer chemo-resistance
cyclophosphamide chemosensitivity structure activity relationships cell culture
2015/5/25
ALDH isoenzymes are known to impact the sensitivity of certain neoplastic cells toward cyclophosphamides and its analogs. Despite its bone marrow toxicity, cyclophos-phamide is still used to treat var...
Discovery of Novel Regulators of Aldehyde Dehydrogenase Isoenzymes
Aldehyde dehydrogenase high-throughput screening computational docking
2015/1/7
Over the past three years we have been involved in high-throughput screening in an effort to discover novel small molecular modulators of aldehyde dehydrogenase (ALDH) activity. In particular, we have...
Genotyping of Polymorphisms in Alcohol and Aldehyde Dehydrogenase Genes by Direct Application of PCR-RFLP on Dried Blood without DNA Extraction
Genotyping Polymorphisms in Alcohol and Aldehyde Dehydrogenase Genes PCR-RFLP Dried Blood DNA Extraction
2010/9/20
We have developed a simple, labor-saving, inexpensive, and rapid single nucleotide polymorphism (SNP) genotyping method that works directly on whole human blood. This single-tube genotyping method wa...
乙醛脱氢酶2（ALDH2）基因研究进展及其与饮酒行为的关系Aldehyde Dehydrogenase (ALDH2) Polymorphism and Drinking Behavior*
乙醛脱氢酶2 多态性 饮酒行为
2007/12/7
摘要亚洲人群中普遍存在突变型的乙醛脱氢酶2（ALDH2*2）。此酶突变后活性缺失，导致乙醛在肝脏内大量累积使突变携带者在喝酒后会有脸红等不适反应，因此这可能影响他们的饮酒行为。由于ALDH2*2等位基因与饮酒行为相关，它也可能与酒精引起的肝脏损伤及某些癌症密切相关，而且，它在不同的亚洲人群中有不同的频率分布。近年来对ALDH2*2等位基因的序列结构、表达及其重要功能等有了更深入的了解，对ALDH2...