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The effect of sertindole on behavioural sensitisation to methamphetamine in mice
behavioural sensitisation methamphetamine sertindole mice
2015/4/15
Similarly to various other addictive substances, methamphetamine (Met) produces, following repeated application, a strong increase in behavioural responses (particularly locomotor behaviour), a phenom...
一种新的α1A肾上腺素受体选择性拮抗剂—Sertindole
α1肾上腺素受体 拮抗剂 受体亚型 Sertindole
2010/2/22
本工作分别在稳定表达α1A,α1B和α1D肾上腺素受体(adrenoceptor,AR)的人胚胎肾脏细胞( human embryonic kidney 293,HEK 293)和大鼠离体血管上,用放射配体结合实验和离体血管收缩功能实验方法以确定sertindole对α1-AR亚型的选择性拮抗作用。结果显示sertindole与克隆α1A-AR的亲和性分别是与克隆α1B-AR和克隆α1D-AR的6...