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White Leghorn male chicks, 2-6 days and 4 weeks old, were injected with MgCl2 (2 mM Mg/kg body weight) and exposed to 100% O2 at 75 lb/in2 (approximately 5 atm). Compared to saline-injected controls, ...
Chickens exposed to hyperbaric oxygen (3 to 5 ATA) or to 100percent oxygen at atmospheric pressure for prolonged periods showed no pathologic pulmonary damage, although hydrogen peroxide did accumulat...
A commercial diver taking part in a saturation dive (O2-He) was exposed intermittently to 1.4 b of oxygen for a total of 55 h. He developed the syndrome associated with oxygen pulmonary toxicity. Deta...
The role of CO2 in hyperbaric oxygen toxicity was investigated by administering acetazolamide (Diamox), Tris buffer [tris(hydroxymethyl)aminomethane], and sodium bicarbonate by i.p. injection, and by ...
New perspectives on hyperoxic pulmonary toxicity--a review.
The effect of ambient illumination on sensitivity to CNS oxygen toxicity was studied in awake male rats. Continuous recording of the EEG was obtained with chronically implanted cortical electrodes. Th...
Central nervous system oxygen toxicity is currently the limiting factor in underwater swimming/diving operations using closed-circuit oxygen equipment. A dive series was conducted at the Navy Experime...
Blood glucose concentration was measured during continuous electrocorticographic (ECoG) recording in conscious rats exposed to 3 and 5 atmosphere absolute oxygen (ATA O2). The preconvulsive oxygen-ind...
Central nervous system oxygen toxicity in hyperbaric oxygen-inert gas mixtures was studied by exposing male rats to various gas mixtures having the same oxygen partial pressure and varying pressures o...
The visual reaction time performance of divers experiencing CNS oxygen toxicity was assessed during the development of closed-circuit 100percent oxygen breathing diving schedules at the U.S. Navy Expe...
Intermittent O2 breathing is a proven means of delaying pulmonary O2 toxicity during exposure to hyperbaric oxygen. The effect of an intermittent exposure in the pressure range toxic to the CNS was st...
Sodium benzylpenicillin, cloxacillin, and azlocillin were infused intravenously in awake rats at 1 and 41 bar until they convulsed. The doses necessary to elicit convulsions were significantly lower a...
It has been suggested that some individuals have above-average sensitivity to hyperbaric oxygen toxicity. An extensive human study completed at the Naval Experimental Diving Unit (NEDU) tested human t...
Hyperbaric oxygen (HBO2) is associated with a recognized risk for clinical central nervous system (CNS) toxicity. The risk for oxygen convulsions during routine hyperbaric treatment of most routine co...
permanent loss of vision. Apart from gastric lavage and oral administration of activated charcoal, current treatment modalities are of doubtful efficacy. Two patients with quinine amaurosis were treat...

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