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The results of previous studies suggest that de novo lipogenesis may play an important role in the etiology of obesity, particularly during overconsumption of different carbohydrates.
Results of leptin administration in mice, rats, and humans provide a rationale for therapeutic augmentation of circulating leptin (OB protein) concentrations in obese humans; this may reduce food i...
Previous studies investigating the hypothesis that a low resting metabolic rate (RMR) is a cause of obesity yielded discrepant findings. Two explanations for these findings are the use of imprecise...
The results of previous studies indicated that energy density, independent of fat content, influences energy intake. In most studies, however, both fat content and energy density were lower than in...
In animals, the whole-body content and accumulation of linoleate can be measured and compared with its intake to determine linoleate -oxidation. This method can also provide quantitative informatio...
Energy restriction is known to induce a decline in fat oxidation during the postdiet period. Reduced fat oxidation may contribute to weight regain.
Alterations in glucose metabolism during early fasting may be an important trigger of the hormonal and metabolic responses to fasting.
Weight reduction reduces bone mineral density (BMD) and increases the risk of osteoporosis.
The influence of the amount and type of carbohydrates in the diet on risk factors for obesity, diabetes, and cardiovascular disease remains unclear.
Plasma leptin in humans is subject to both longand short-term regulation; it correlates with indexes of body fat that can only change slowly. However, short-term fasting causes large and rapid decr...
Most methods available to clinicians for estimating body-composition changes have been validated against estimates from densitometry, based on a 2-component (fat mass and fat-free mass) model.
Weight loss in obese subjects is associated with a reduction in resting metabolic rate (RMR). Whether the reduction can be explained solely by a reduction in lean body mass remains controversial.
Physical training can improve hemostatic function in adults, thereby reducing heart disease risk, but no information is available in children on whether physical training can enhance hemostatic fun...
A low resting metabolic rate (RMR) for a given body size and composition is partly genetically determined and has been suggested to be a risk factor for weight gain. Moreover, a low relative RMR ha...

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