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Normal gonadal functions and fertility after 23 months of treatment of prepubertal male and female dogs with the GnRh agonist [D-Trp6, des-Gly-NH2(10)]GnRH ethylamide
Normal gonadal functions fertility prepubertal male female dogs
2009/2/23
The GnRH agonist [D-Trp6, des-Gly-NH2(10)]GnRH ethylamide was administered to prepubertal male and female dogs daily for 23 months by subcutaneous injection. During GnRH agonist treatment, plasma ster...
Reversibility of long-term effects of GnRH agonist administration on testicular histology and sperm production in the nonhuman primate
GnRH agonist LH testosterone testis morphology electron microscopy monkeys
2009/2/23
The present investigation evaluates the long-term effects of GnRH agonist treatment on testicular histology, sperm production and the subsequent recovery of these parameters. Four adult rhesus monke...
Testosterone Pretreatment and the Response of Pituitary LH to Gonadotropin-Releasing Hormone（GnRH）in the Male Dog
GnRH LH-response testosterone dog
2009/2/19
To characterize the effects of testosterone (T) pretreatment on the response of pituitary LH secretion to exogenous gonadotropin-releasing hormone (GnRH), intact male dogs were injected subcutaneo...
Effect of acute androgen withdrawal by GnRH antagonist on epididymal sperm motility and morphology in the cynomolgus monkey
acute androgen withdrawal GnRH epididymal sperm motility
2009/2/18
Hormonal male contraception requires an induction phase before azoospermia and contraceptive safety are achieved. The nature of spermatozoa that may be ejaculated during this induction phase was s...
Gonadal and pituitary responsiveness of stallions is not down-regulated by prolonged pulsatile administration of GnRH
Equine hypothalamic-pituitary-gonadal axis ref ractoriness
2009/2/17
The objective of this study was to determine if prolonged pulsatile administration of homologous gonadotropin-releasing hormone (GnRH) at therapeutic or 5x therapeutic doses would cause down-regul...
Follicle-stimulating hormone（FSH）escape during chronic gonadotropin-releasing hormone（GnRH）agonist and testosterone treatment
GnRH agonist FSH male contraception spermatogenesis
2009/2/12
Observations that serum follicle-stimulating hormone (FSH) levels begin to rise after initial suppression during chronic gonadotropin-releasing hormone (GnRH) agonist treatment of men with prostat...
FSH is produced by GnRH-deficient men and is suppressed by testosterone
FSH GnRH-deficient men testosterone
2009/2/12
Because there is an unexpected action of testosterone (T) to increase follicle-stimulating hormone (FSH) production in the absence of gonadotropin-releasing hormone (GnRH) in the rat, the effects of T...
Comparative effects of two different delivery systems on gonadotropin-releasing hormone（GnRH） antagonist-induced suppression of gonadotropins and testosterone in man
GnRH antagonists luteinizing hormone (LH)
2009/2/12
The Nal-Glu gonadotropin-releasing hormone (GnRH) antagonist, when given in daily subcutaneous (SC) doses of 5 mg or higher, maximally suppresses serum luteinizing hormone (LH) and follicle-stimul...
Seasonal effects on seminal quality, plasma hormone concentrations, and GnRH-induced LH response in fertile and subfertile stallions
Stallions subfertility season hormones semen
2009/2/10
Seasonal effects on hormonal and seminal parameters in subfertile stallions have not been well documented and could provide information that is needed to understand the underlying endocrine mechan...
GnRH-A induced arrest of spermiogenesis in rats is associated with altered androgen binding protein distribution in the testis and epididymis
GnRH-antagonist Sertoli cell spermatogenesis
2009/2/10
This study examines the effects of a potent gonadotropin releasing hormone (GnRH)-antagonist (GnRH-A, Ac-D[2] Nal1, 4-CL-D Phe2, D-Trp3, D-Arg6, D-Ala10) upon the distribution of androgen binding pr...
Response of circulating gonadotropin levels to GnRH agonist treatment in prostatic cancer
LH FSH testosterone bioactive LH buserelin
2009/2/7
Luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone (T) responses to 6-month treatments with a gonadotropin-releasing hormone (GnRH) agonist (buserelin) and subsequent orc...
GnRH agonists and antagonists stimulate recovery of fertility in irradiated LBNF1 rats
Spermatogenesis toxicology testosterone Leydig
2008/12/29
The goal of this study was to determine whether both gonadotropin-releasing hormone (GnRH) agonists and antagonists could enhance fertility in rats given sterilizing doses of irradiation, to quantif...
Age-related decrease in hypothalamic gonadotropin-releasing hormone（GnRH）gene expression, but not pituitary responsiveness to GnRH, in the male Brown Norway rat
Age-related decrease hypothalamic gonadotropin-releasing hormone（GnRH）gene expression pituitary responsiveness GnRH male
2008/12/25
As is the case in humans, aging male Brown Norway (BN) rats exhibit both primary and secondary (hypothalamic/pituitary) testicular failure. We hypothesized that secondary testicular failure in aging...
Effects of Estradiol Infusion in GnRH Immunized Boars on Spermatogenesis
Estrogen receptor spermatogenic stage apoptosis mitosis
2008/12/24
Active immunization of boars against gonadotropin-releasing hormone (GnRH) inhibits luteinizing hormone (LH) and testicular steroids, so that mitosis of spermatogonia is reduced and apoptosis increa...
Use of a GnRH Agonist and hCG to Obtain an Index of Testosterone Secretory Capacity in the Koala（Phascolarctos cinereus）
Marsupial hormone stimulation test
2008/12/24
Testosterone secretion in mammals typically occurs in random pulses such that a single blood sample provides limited information on reproductive endocrine status. However, it has been shown in sever...