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Stimulation of the proliferation and differentiation of Leydig cell precursors after the destruction of existing Leydig cells with ethane dimethyl sulphonate（EDS）can take place in the absence of LH
proliferation differentiation Leydig cell precursors
2009/2/23
In hypophysectomized rats, 2 days after the administration of the cytotoxic drug ethane dimethyl sulphonate (EDS), the proliferative activity of Leydig cell precursors increased six-fold. Thus, fact...
The regulation of the proliferation and differentiation of rat Leydig cell precursor cells after EDS administration or daily HCG treatment
Leydig cell Leydig cell precursor LH hCG EDS proliferation
2009/2/23
The proliferation and differentiation of possible Leydig cell precursors in adult rats were studied after destruction of the existing Leydig cells with EDS or after daily treatment with hCG. After 2...
Effects of macrophage depletion at different times after treatment with ethylene dimethane sulfonate(EDS)on the regeneration of Leydig cells in the adult rat
Ethylene dimethane sulfonate Leydig cells regeneration macrophage depletion
2009/2/13
Testicular macrophages were selectively depleted in the right testes of adult rats by an intratesticular injection of dichloromethylene diphosphonate-containing liposomes (Cl2MDP-lp), whereas the le...
Does ethane 1,2-dimethanesulphonate（EDS）have a direct cytotoxic effect on the seminiferous epithelium of the rat testis?
spermatogenesis cytotoxic testosterone testes rat
2009/2/6
The authors examined the possibility that ethane 1,2-dimethanesulphonate (EDS) has a cytotoxic effect on spermatogenesis that is not secondary to androgen withdrawal resulting from the well known cy...