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Previous studies performed with crude homogenates have demonstrated the presence of beta-adrenergic receptors in the rat ventral prostate. The precise localization of these receptors in prostatic ti...
Male rats exposed in utero to delta 9-tetrahydrocannabinol (delta 9-THC) had lower levels of testosterone (T) and luteinizing hormone (LH) prior to puberty (P less than 0.01). At puberty, the levels...
Stromal-epithelial cell interactions may be important for the regulation of normal and abnormal prostatic growth. While androgen transformation by rat ventral prostate and canine prostate has been i...
Stromal-epithelial cell interactions may be important for the regulation of normal and abnormal prostatic growth. While androgen transformation by rat ventral prostate and canine prostate has been i...
Immunocytochemical techniques labeled androgen receptor and cell-specific cytokeratins in the basal cells of rat ventral prostate. In addition, nonradioactive in situ hybridization verified the prod...
The induction of prostatic lesions in the rat by hormonal manipulation and/or chemical carcinogens in different strains is well documented in literature. However, the selection of a strain for such ...
In order to determine if epidermal growth factor (EGF) or basic fibroblast growth factor (bFGF) are capable of stimulating prostatic growth in situ, we complexed EGF and bFGF to a Matrigel (MG) ve...
After castration the rat ventral prostate undergoes regression. This process occurs due to the induction of apoptosis, or active cell death, in the epithelial cells of the gland. Several genes, incl...
The objectives of this study were to compare changes in the ventral prostate (VP) of young adult Sprague Dawley rats after 28 days of treatment with finasteride (F), a potent 5 alpha-reductase inhib...
Several compounds, such as 4-MAPC (4-methyl-3-oxo-4-aza-5 alpha-pregnane-20- carboxylate), that inhibit conversion of testosterone (T) to dihydrotestosterone (DHT) by 5 alpha-reductase have been demon...
Adult Sprague-Dawley male rats, weighing about 350 g, were rendered cryptorchid by suturing the testes to the lateral abdominal wall. Twenty-eight days later, cryptorchidism resulted in a signific...
Smooth muscle cells (SMC) play roles in prostatic development and function. The cells also respond to tissue injury and hormonal variations, alternating between a fully differentiated and contractil...
The adult rat ventral prostate, which has been used extensively as a model for hormone-dependent prostate cancer, is composed of hormone-dependent columnar secretory epithelial cells and a mixture...

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