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There are two important categories of genes involved in cancer development, oncogenes and tumor suppressor genes. When oncogenes gain function, e.g. through mutation, they actively promote cancer – dr...
Fragile X Syndrome is the most common form of inherited mental retardation worldwide. A Fragile X mouse model, fmr1, with a disruption in the X-linked Fmr1 gene, has three substantial deficits observe...
The relative biomechanical effects of antiresorptive treatment on cortical thickness vs. trabecular bone microarchitecture in the spine are not well understood. To address this, T-10 vertebral bodies ...
This study addressed the effects of changes in trabecular microarchitecture induced by suppressed bone turnover—including changes to the remodeling space—on the trabecular bone strength–volume fractio...
Fat-suppression technology of magnetic resonance is very important in clinical practice.This article is written to interpret the principle, advantages/disadvantages and clinical applications of some r...
Thymic output is a dynamic process, with high activity at birth punctuated by transient periods of involution during infection. Interferon-α (IFN-α) is a critical molecular mediator of pathogen-induce...
The finite sampling of k-space in MRI causes spurious image artifacts, known as Gibbs ringing, which result from signal truncation at the border of k-space. The effect is especially visible for acquis...
Suppression of the high pressure nervous syndrome in human deep dives by He-N2-O2.
The anesthetic induction dose of thiopental in rats was studied at 1 ATA air, 1 ATA helium-oxygen (He-O2), 4 ATA air, and at 4 ATA air plus 67 ATA helium (71 ATA). The compression rate was 0.3 ATA/min...
One of possible problems in fMRI-MEG integrative analysis is mismatches between activated regions detected by fMRI and MEG. These mismatches cause serious degradation of estimation accuracy, especiall...
We studied the effects of bisphosphonate administration on cementum-like tissue formation and dentin resorption induced by BMP-2 in rats. Incadronate (1μg/kg/day) was administered intraperitoneally t...
We developed a time-suppression test using alamarBlue®, which will allow estimation of the cidal or static nature of antimicrobials very easily and quickly. As an example, the effects of vancomy...
Tritiated androgen receptor complex was partially purified by ammonium sulfate precipitation at 15 to 37% saturation from rat testicular or prostatic cytosols. A greater amount of prostatic tritiate...
Using subcutaneously implanted osmotic pumps, four male rhesus monkeys were continuously infused for 18 months with 100 micrograms/day of [(imBzl)-D-His6-Pro9-NEt]-LHRH (LHRH-A), a potent agonist of...
The precise hormonal milieu required for quantitatively normal spermatogenesis in man is unclear. The authors previously have shown that both supraphysiologic dosages of human chorionic gonadotropin...

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