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COMPARISON OF EFFECTIVENESS OF LOVASTATIN AND GEMFIBROZIL ON HDL-C LEVEL IN DIABETIC TYPE 2 PATIENTS
Gemfibrozil TYPE 2 PATIENTS Diabetes
2009/12/30
Background: Diabetes mellitus is the most common human metabolic disease. Chronic hyperglycemia and carbohydrate metabolism disorder accompany with plasma lipid and lipoprotein disorder. Cardiovascula...
Comparison between Fenugreek and Lovastatin in restoration of endothelial function in an experimental old rat model
Fenugreek Endothelial function rat
2009/12/24
The aim of this study was to compare the effectiveness of Fenugreek (Trigonella foenum-graecum) with that of lovastatin in restoration of endothelia function in the aorta taken form aged N-Mair rats. ...
Lovastatin对肝癌HepG2细胞作用后基因差异表达的初步研究
HepG2细胞 洛伐他汀 基因表达
2009/8/27
目的： 用cDNA芯片观察lovastatin作用前后HepG2细胞的差异表达基因。 方法： 20 μmol/L的lovastatin作用于HepG2细胞18 h，各提取实验组与对照组细胞总RNA，用cDNA直接标记法制备探针，进行杂交，杂交信号经扫描后，用软件分析基因表达情况。应用RT-PCR验证部分差异表达基因。 结果： Lovastatin作用后表达上调的基因有30个，表达下调的基因有11个...
VITAMIN E SUPPLEMENT BLOCKS THE RESPONSE OF HDL TO LOVASTATIN THERAPY IN HYPERCHOLESTROLEMIC PATIENTS
Vitamin E Lovastatin Hypercholesterolemia HDL-Cholesterol
2010/4/19
HDL can prevent LDL-c oxidation. The low HDL-c State also may benefit clinically from supplemented antioxidant. This study was designed to evaluate the combination therapy of statin and vitamin E in h...
Influence of β - cyclodextrin complexation on lovastatin release from osmotic pump tablets (OPT)
β-Cyclodextrin Inclusion complex Elementary osmotic pump (EOP)
2010/4/8
An extended-release osmotic dosage form was designed and the effect of β-cyclodextrin (BCD) inclusion complexation on the solubility of lovastatin in aqueous media was investigated. The lovastatin BCD...
A COMPARISON BETWEEN FLUVASTATIN AND LOVASTATIN EFFECTS IN IRANIAN PATIENTS WITH HYPERCHOLESTEROLEMIA
Fluvastatin. lovastatin lovastatin fluvastatin
2010/5/7
The aim of this study was to determine the effect of lovastatin and fluvastatin compared with placebo in patients with high levels of total cholesterol and low density lipoprotein cholesterol (LDL - C...