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Triptolide Directly Inhibits dCTP Pyrophosphatase
Pyrophosphatase Triptolide Directly Inhibits
2014/11/25
Triptolide is a potent natural product, with documented antiproliferative, immunosuppressive, anti-inflammatory, antifertility, and antipolycystic kidney disease effects. Despite a wealth of knowledge...
Decreased Autocrine EGFR Signaling in Metastatic Breast Cancer Cells Inhibits Tumor Growth in Bone and Mammary Fat Pad
autocrine signaling bone marrow cells breast cancer
2014/11/6
Breast cancer metastasis to bone triggers a vicious cycle of tumor growth linked to osteolysis. Breast cancer cells and osteoblasts express the epidermal growth factor receptor (EGFR) and produce ErbB...
Thymoquinone Suppresses Cellular Proliferation, Inhibits VEGF Production and Obstructs Tumor Progression and Invasion in the Rat Model of DMH-Induced Colon Carcinogenesis
Thymoquinone PCNA-LI VEGF Serum Levels
2013/2/19
A myriad of medicinal effects has been attributed to Thymoquinone (TQ), the major biological-active component of Nigella sativa. TQ has been shown to exhibit potent anti-tumor activities. The present ...
Growth and differentiation factor-11 is developmentally regulated in skeletal muscle and inhibits myoblast differentiation
GDF-11 Developmental Expression Post-Natal Muscle Growth Sexual Dimorphism Myoblast Differentiation
2013/1/30
Growth and differentiation factor-11 (GDF-11) is a secreted protein that is closely related to myostatin, a known inhibitor of skeletal muscle development. The role of GDF-11 in regulating skeletal mu...
Diclofenac inhibits Kv1.3 and Kir2.1 expressions in human macrophages and affects the membrane potential and foam cell formation
离子通道 膜电位 巨噬细胞 双氯酚酸 细胞分化
2012/8/20
目的分研究双氯芬酸对人巨噬细胞电压依赖性钾通道Kv1.3、内向整流钾通道Kir2.1表达的影响及意义。方法以健康人外周血单核细胞源性巨噬细胞对象，采用Real-time RT-PCR及Western blot技术研究双氯芬酸对Kv1.3和Kir2.1表达的影响；电压敏感染料膜电位标测技术分析膜电位的变化，并用酶荧光化学法检测摄取氧化修饰低密度脂蛋白（OxLDL）的巨噬细胞内胆固醇酯（CE）的构成比...
Publication in Neuropsychopharmacology Confirms CeNeRx's Novel RIMA Antidepressant TriRima™ Selectively and Reversibly Inhibits MAO-A
Neuropsychopharmacology Confirms MAO-A CeNeRx's Novel RIMA Antidepressant TriRima&trade
2009/12/16
CeNeRx BioPharma, Inc., a clinical stage company developing innovative treatments for diseases of the central nervous system, today announced that a newly published PET imaging study in human subjects...
Electrolyzed-reduced water inhibits acute ethanol-induced hangovers in Sprague-Dawley rats
Electrolyzed-reduced ethanol-induced
2009/12/16
Ethanol consumption disturbs the balance between the pro- and anti-oxidant systems of the organism, leading to oxidative stress. Electrolyzed-reduced water (ERW) is widely used by people in East Asia ...
Soft-diet Feeding Inhibits Adult Neurogenesis in Hippocampus of Mice
Mastication Neurogenesis Neurotrophin
2010/1/21
Our previous study showed that mice fed on a soft diet after weaning had reduced levels of brain-derived neurotrophic factor (BDNF) protein in the hippocampus after 3 months of age compared with mice ...
An M-CSF Receptor c-Fms Antibody Inhibits Mechanical Stress–Induced Root Resorption during Orthodontic Tooth Movement in Mice
c-Fms Odontoclast Root resorption Mouse Orthodontics
2010/3/5
Objective: To examine the effect of anti-c-Fms antibody on odontoclastogenesis and root resorption in an orthodontic tooth movement mouse model.
Materials and Methods: We used orthodontic tooth mov...
Soft-diet Feeding Inhibits Adult Neurogenesis in Hippocampus of Mice
Mastication Neurogenesis Neurotrophin
2010/12/1
Our previous study showed that mice fed on a soft diet after weaning had reduced levels of brain-derived neurotrophic factor (BDNF) protein in the hippocampus after 3 months of age compared with mice ...
Teucrium polium Inhibits Nerve Conduction and Carrageenan Induced Inflammation in the Rat Skin
Teucrium polium Sensory nerve Neurogenic inflammation
2009/6/29
The effects of acute and chronic perineural treatment of the rat saphenous nerve with Teucrium polium (L.) extract on the conduction property of primary afferent nerve fibers and carrageenan-induced s...
Sildenafil Inhibits the Proliferation of Cultured Human Endothelial Cells
atherosclerosis basic fibroblast growth factor endothelial proliferation plaque angiogenesis
2009/4/20
The proliferation of endothelial cells plays a crucial role in the development of intraplaque angiogenesis (IPA). IPA is a major source of intraplaque hemorrhage and therefore contributes to the desta...
Dibutyltin（DBT）Dichloride Inhibits Cytokine Productions in Murine Macrophage Cell Line, J774.1.
dibutyltin macrophages tumor necrosis factor α interleukin-1β real time PCR ELISA
2009/3/23
The immune system is a target of dibutyltin (DBT) intoxication. We evaluated the effects of DBT dichloride in macrophages using the murine macrophage cell line, J774.1. Cultured J774.1 cells were expo...
Loxoprofen inhibits facilitated micturition reflex induced by acetic acid urinary bladder infusion of the rats
Loxoprofen inhibits facilitated micturition acetic acid urinary bladder infusion rats
2009/3/2
Prostaglandins (PGs) are well known as one of the chemical mediators of inflammation. Nonsteroidal anti-inflammatory drugs (NSAIDs), PG synthesis inhibitors, are used for anti-nocoception and/or ant...
A gap junction blocker inhibits isolated whole bladder activity in normal rats and rats with partial bladder outlet obstruction
bladder activity normal rats rats with partial bladder outlet obstruction
2009/3/2
We examined the effect of 18alpha-glycyrrhetinic acid (18alpha-GA), a gap junction blocker, or propiverine hydrochloride on the activity of isolated whole bladders obtained from intact rats and rats...