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Identification of material parameters based on Mohr-Coulomb failure criterion for bisphosphonate treated canine vertebral cancellous bone
material parameter identification Mohr-Coulomb failure criterion trabecular bone
2014/12/4
Nanoindentation has been widely used to study bone tissue mechanical properties. The common method and equations for analyzing nanoindentation, developed by Oliver and Pharr, are based on the assumpti...
Mandible matrix necrosis in beagle dogs After 3-years of daily oral bisphosphonate treatment
osteonecrosis of the jaw remodeling suppression
2014/12/4
Purpose An increasing number of reports have implicated bisphosphonates as contributing to osteonecrosis of the jaw. The goal of this study was to evaluate mandible necrosis in beagle dogs treated for...
Short-courses of dexamethasone abolish bisphosphonate-induced reductions in bone toughness
zoledronic acid mechanical properties toughness remodeling suppression
2014/12/4
Atypical femoral fractures, which display characteristics of brittle material failure, have been associated with potent remodeling suppression drugs. Given the millions of individuals treated with thi...
Adverse mandibular bone effects associated with kidney disease are only partially corrected with bisphosphonate and/or calcium treatment
zolendronate c-reactive protein parathyroid hormone oral bone anti-remodeling
2014/12/4
Background/Aims: Patients with chronic kidney disease (CKD) have high prevalence of periodontal disease that may predispose to tooth loss and inflammation. The goal of this study was to test the hypot...
Bisphosphonate Treatment Modifies Canine Bone Mineral and Matrix Properties and their Heterogeneity
bisphosphonates bone remodeling
2014/12/4
Bone loss and alterations in bone quality are major causes leading to bone fragility in postmenopausal women. Although bisphosphonates are well known to reduce bone turnover and prevent bone loss in p...
Morphological Assessment of Basic Multicellular Unit Resorption Parameters in Dogs Shows Additional Mechanisms of Bisphosphonate Effects on Bone
basic multicellular unit alendronate
2014/12/4
Bisphosphonates (BPs) slow bone loss by reducing initiation of new basic multicellular units (BMUs). Whether or not BPs simply prevent osteoclasts from initiating new BMUs that resorb bone or also red...
Biomechanical analysis of combined treatment of high calcium and bisphosphonate in tibia of steroid-treated growing-phase rats
Bisphosphonate pQCT Rat
2009/9/11
Childhood systemic diseases are commonly treated with steroids. Consequently, steroid-induced osteoporosis is often observed as a side effect of steroid therapy. However, osteoporosis of tibia resulti...
Bone composition and metabolism after hyperbaric oxygenation in rats with 1-hydroxyethylidene-1,1-bisphosphonate-induced rickets
HBO hyperbaric Bone composition animal rat
2009/6/8
We examined bone composition and metabolism after hyperbaric oxygenation (HBO) in Wistar rats with 1-hydroxyethylidene-1, 1-bisphosphonate (HEBP)-induced rickets. Twenty rats at 4 wk of age were divid...
Suppression of cementum-like tissue formation on BMP-2-applied dentin surface by bisphosphonate
rhBMP-2 dentin resorption cementum-like tissue bisphosphonate
2009/5/20
We studied the effects of bisphosphonate administration on cementum-like tissue formation and dentin resorption induced by BMP-2 in rats.
Incadronate (1μg/kg/day) was administered intraperitoneally t...
The effect of bisphosphonate on prevention of glucocorticoid-induced osteoporosis
Glucocorticoid-induced osteoporosis Autoimmune disease Bisphosphonate Calcium Vitamin D
2015/9/9
Background: Glucocorticoid therapy can induce osteoporosis. Bone mineral density (BMD) measurement has been used to assess the risk of fracture in these patients. The most important mechanism is dimin...