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DHA-rich n–3 fatty acid supplementation decreases DNA methylation in blood leukocytes: the OmegAD study
fish oil DHA EPA DNA methylation LINE-1 Alzheimer disease
2018/11/20
Background: Dietary fish oils, rich in long-chain n–3 (ω-3) fatty acids (FAs) [e.g., docosahexaenoic acid (DHA, 22:6n–3) and eicosapentaenoic acid (EPA, 20:5n–3)], modulate inflammatory reactions thro...
Does DNA Methylation Plays a Critical Role in Osteoblastic Differentiation of Mesenchymal Stem Cells (MSCs)?
Mesenchymal Stromal Cells Cell Differentiation Osteoblastic
2015/10/8
Mesenchymal stem cells (MSCs) are characterized by ability to differentiate into several cell types and self-renewability. These stem cells have a limited capacity in cell lineage differentiation incl...
Genomic DNA methylation decreases in response to moderate folate depletion in elderly women
DNA methylation genomic DNA folate homocysteine humans elderly women
2016/6/8
Background: Methylation of genomic DNA is dependent on an
adequate supply of folate coenzymes. Previous data support the
hypothesis that abnormal DNA methylation plays an integral
role in carcinoge...
Folate, DNA methylation, and gene expression: factors of nature and nurture
nature and nurture nature and nurture
2016/6/8
Folate provides the one-carbon units required for purine and
thymidylate syntheses and for methylation of a wide variety of
essential biological substances, including phospholipids, proteins,
DNA, ...