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Patients with carboxylase deficiency are treated with pharmacologic doses of biotin.
Frank, symptomatic biotin deficiency probably occurs rarely. The only well-documented cases have occurred in association with total or near total intravenous feeding without biotin supplementation, ...
Background: The results of clinical studies have provided evidence that marginal biotin deficiency is more common than was previously thought. A previous study of 10 subjects showed that the urin...
Background: Biotin deficiency is teratogenic in several mammalian species. Approximately 50% of pregnant women have an abnormally increased urinary excretion of 3-hydroxyisovaleric acid (3-HIA), ...

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