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提供了由哺乳动物YAP蛋白或具有转录控制活性的片段的融合蛋白的与细胞全能性和转录激活结构域相关的基因编码的蛋白、编码核苷酸序列、表达载体及其组合物,以及使用该融合蛋白诱导多能干细胞的方法。
本发明提供了一种hnRNP A2*蛋白质,编码该蛋白的核酸及用途。所述蛋白含有蛋白,蛋白质片段或蛋白质的类似物或衍生物的氨基酸序列如SEQ ID NO。1。本发明hnRNP A2*蛋白质能主动解开端粒G-四,结合最小结合位点,在3′端粒的尾端,露出五个核苷酸可配合端粒酶RNA模板和促进端粒延伸端粒酶的作用下,从而保持细胞的分裂潜能。
One of the most expensive steps in manufacturing protein drugs such as antibodies or insulin is the purification step: isolating the protein from the bioreactor used to produce it. This step can accou...
About 70 percent of all human proteins include at least one sequence consisting of a single amino acid repeated many times, with a few other amino acids sprinkled in. These “low-complexity regions” ar...
MIT chemists have discovered the structure of a protein that can pump toxic molecules out of bacterial cells. Proteins similar to this one, which is found in E. coli, are believed to help bacteria bec...
The versatility of the nervous system comes from not only the diversity of ways in which neurons communicate in circuits, but also their “plasticity,” or ability to change those connections when new i...
In recent years, scientists have developed monoclonal antibodies — proteins that mimic the body’s own immune defenses — that can combat a variety of diseases, including some cancers and autoimmune dis...
Cells undergo natural aging and death, processes that impact a multitude of cellular factors. A new Stony Brook University-led study published in Proceedings of the National Academy of Sciences (PNAS)...
A new study by chemists at the University of Arkansas shows that X-ray crystallography, the standard method for determining the structure of proteins, may provide inaccurate information about a critic...
While it is known that heat treatment of cereal grains generally improves the nutritional value for ruminants, simultaneous information on rumen degradability and intestinal digestibility of the rumen...
Researchers have applied Nobel prize-winning microscope technology to uncover an ion channel structure that could lead to new treatments for kidney stones. In a recent study published in Nature Struct...
What makes the body of a person or any other organism work can for the most part be summed up in a word: proteins.These big molecules carry out almost all processes in living organisms, including movi...
A nanoscale antibody first found in camels combined with a protein-degrading molecule is an effective new platform to control protein levels in cells, according to Rice University scientists. The tech...
So unheard of was a discovery that researchers made in a protein associated with glaucoma that for over two years they ran it through a gauntlet of lab tests and published a new research paper on it. ...
A new study describes how head-on collisions between protein machines on chromosomes can disrupt DNA replication and boost the rate of gene mutations that help bacteria survive hostile environments, r...

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