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A plant-based, oral delivery of insulin regulates blood sugar levels similar to natural insulin（图）
Research Dental Medicine 天然胰岛素
2023/6/27
Insulin production has, for the last 50 or so years, come with some risks to the patient. Even so, the medication is lifesaving for the estimated 537 million adults living with diabetes worldwide, wit...
Only one human fat cell subtype responds to insulin stimulation
AdipoPLIN fat cells insulin diabetes
2021/8/11
It is well known that fat cells can influence our sensitivity to insulin. Now, researchers have discovered that there are three different subtypes of mature fat cells in white adipose tissue and that ...
The effect of magnesium supplementation on blood pressure in individuals with insulin resistance, prediabetes, or noncommunicable chronic diseases: a meta-analysis of randomized controlled trials
blood pressure cardiovascular diseases insulin resistance
2018/11/16
Background: To our knowledge, the effect of magnesium supplementation on blood pressure (BP) in individuals with preclinical or noncommunicable diseases has not been previously investigated in a meta-...
Fructose replacement of glucose or sucrose in food or beverages lowers postprandial glucose and insulin without raising triglycerides: a systematic review and meta-analysis
sugar replacement, fructose, glucose, sucrose, insulin, triglycerides, diabetes, body weight
2018/11/15
Background: Conflicting evidence exists on the effects of fructose consumption in people with type 1 and type 2 diabetes mellitus. No systematic review has addressed the effect of isoenergetic fructos...
Alterations in human milk leptin and insulin are associated with early changes in the infant intestinal microbiome
milk leptin insulin the infant intestinal microbiome
2018/11/12
We read with great interest the study by Lemas et al. (1) that reported early changes in the gut microbiota composition and functions of exclusively breastfed infants born from obese mothers compared ...
Protein ingestion acutely inhibits insulin-stimulated muscle carnitine uptake in healthy young men
doubly labeled water energy requirement resting energy expenditure short bowel syndrome total energy expenditure
2018/11/26
Background: Increasing skeletal muscle carnitine content represents an appealing intervention in conditions of perturbed lipid metabolism such as obesity and type 2 diabetes but requires chronic L-car...
Effect of fructose consumption on insulin sensitivity in nondiabetic subjects: a systematic review and meta-analysis of diet-intervention trials
fructose glucose clamp glucose disposal insulin insulin resistance meta-analysis
2018/12/19
Background: High fructose consumption has been suggested to contribute to several features of metabolic syndrome including insulin resistance, but to our knowledge, no previous meta-analyses have inve...
Do ω-3 PUFAs affect insulin resistance in a sex-specific manner? A systematic review and meta-analysis of randomized controlled trials
adults diabetes omega-3 PUFAs DHA EPA insulin resistance insulin sensitivity
2018/12/19
Background: Evidence has suggested that omega-3 (n–3) polyunsaturated fatty acids (PUFAs) improve obesity-induced insulin resistance (IR); however, results from human intervention trials have been equ...
Gut permeability is related to body weight, fatty liver disease, and insulin resistance in obese individuals undergoing weight reduction
obesity liver steatosis insulin resistance intestinal permeability gut barrier
2018/11/12
Background: Obesity and associated metabolic disorders are related to impairments of the intestinal barrier.
Objective: We examined lactulose:mannitol (Lac:Man) permeability in obese individuals with...
Interaction of an S100A9 gene variant with saturated fat and carbohydrates to modulate insulin resistance in 3 populations of different ancestries
gene-diet interaction insulin resistance SFA:carbohydrate ratio S100A9 gene type 2 diabetes
2018/12/13
Background: S100 calcium-binding protein A9 (S100A9) has previously been identified as a type 2 diabetes (T2D) gene. However, this finding requires independent validation and more in-depth analyses in...
Effect of vitamin D replacement on indexes of insulin resistance in overweight elderly individuals: a randomized controlled trial
HOMA insulin resistance prediabetes IOM RDA high-dose vitamin D
2018/12/3
Background: It is unclear whether and at what dose vitamin D supplementation affects insulin resistance (IR).
Insulin sensitivity is a Rubik’s Cube
Insulin sensitivity complex metabolic exercise diet
2018/11/30
Insulin sensitivity is determined by complex metabolic interactions dictated by a multitude of inputs that include inherited genetic and epigenetic determinants as well as many varying modifiers such ...
Combined epigallocatechin-3-gallate and resveratrol supplementation for 12 wk increases mitochondrial capacity and fat oxidation, but not insulin sensitivity, in obese humans: a randomized controlled trial
insulin sensitivity mitochondrial capacity obesity polyphenols resveratrol
2018/12/3
Background: The obese insulin-resistant state is characterized by impairments in lipid metabolism. We previously showed that 3-d supplementation of combined epigallocatechin-3-gallate and resveratrol ...
Polymorphism of Insulin-like Growth Factor Binding Protein-4 Gene in 17 Pig Breeds and Its Relationship with Growth Traits
IGFBP-4 Gene Performance Traits Swine PCR-SSCP
2016/4/26
Insulin-like growth factor binding protein-4 (IGFBP-4) is a member of the IGF super family, and regulates the action of IGFs. The polymorphism of porcine IGFBP-4 gene in 17 pig breeds (total n = 570) ...
Adipose tissue α-linolenic acid is inversely associated with insulin resistance in adults
adiposity biomarker insulin resistance n–3 fatty acids waist circumference
2018/11/29
Background: There is emerging evidence of the beneficial effects of n–3 (ω-3) fatty acids (FAs) on cardiometabolic risk factors. Nevertheless, not much is known about the association between adipose t...