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Ischemic injury is a common and debilitating outcome of natural illness and as a complication of commonly performed medical procedures. Whereas naturally occurring ischemic insults are often the resul...
Ischemic preconditioning (IPC, which was originally identified by Murry et al.) provides powerful protection to the ischemic myocardium. Although a variety of intracellular signaling pathways have bee...
Ischemic preconditioning (PC) reduces myocardial infarction by a mechanism that involves opening of mitochondrial ATP-dependent potassium channels (mK ), reactive oxygen species (ROS), and possibly a...
Induction of endogenous antioxidants is one of the key molecular mechanisms of cell resistance to hypoxia/ischemia. The effect of severe hypoxia on the expression of cytosolic antioxidant thioredoxin...
The reason why low-to-moderate alcohol drinking is associated with reduced cardiovascular mortality is not elucidated. While data suggested that ethanol drinking may have a protective effect on globa...
A hypothesis was tested that a reaction product between superoxide (O2  ) and nitric oxide (NO) mediates post-ischemic coronary endothelial dysfunction that ischemic preconditioning (IPC) protects...
1.what is ischemic preconditioning (IPC)? A phenomenon by which a brief episodes of myocardial ischemia increases the ability of the heart to tolerate a subseqent prolonged period of ischemic injury....
In protocol 1, New Zealand White rabbits underwent either no intervention (sham group) or 10 min of ischemia followed by 5 min of reperfusion, preceded (PC) or not (C; control) by one episode of 5 mi...

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