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MIT chemists have discovered the structure of a protein that can pump toxic molecules out of bacterial cells. Proteins similar to this one, which is found in E. coli, are believed to help bacteria bec...
Drug Resistance in Salmonella typhi: Tip of the Iceberg
Drug resistance Plasmid Salmonella typhi
2015/7/30
Salmonella typhi is one of the most resistant organisms with multi-drug resistant strains reported from many countries. Initially, individual plasmids were known to code for resistance,but since 1988 ...
Interplay between mutational pathway and spatial drug distribution controls time to evolution of drug resistance
Interplay mutational pathway spatial drug distribution controls time evolution of drug resistance
2012/2/28
Spatial gradients of drug concentration are believed to play an important role in the evolution of drug resistance. We use a stochastic model to show that in a growing population of malignant cells th...