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华南理工大学医学院张译月教授学位论文在生物化学杂志上，揭示Runx1在中性粒细胞成熟过程中的调节机制（图）
华南理工大学医学院 张译月教授 生物化学杂志 Runx1 中性粒细胞 成熟过程 调节机制
2021/2/23
中性粒细胞作为血液中最丰富的吞噬细胞，是先天免疫系统中必不可少的第一道防线。成熟的中性粒细胞在杀灭和消化病原体，对损伤引起反应和介导炎症反应中发挥了重要作用，其最初到达损伤和局部，具有很强的趋化性和吞噬功能，在感染时趋化至感染部位，依赖丰富的颗粒酶，活性氧，中性粒细胞外诱捕网等杀灭外来物质[ 1 ]。中性粒细胞的定向分化，发育和成熟是一系列复杂而有序的动态过程，经过要严密的转录因子调控才能得以实现...
Association of the Single Nucleotide Polymorphisms in RUNX1, DYRK1A, and KCNJ15 with Blood Related Traits in Pigs
Positional Candidate Gene Blood Related Traits Association Test Landrace Korean Native Pigs
2016/12/28
The aim of this study was to detect positional candidate genes located within the support interval (SI) regions based on the results of red blood cell, mean corpuscular volume (MCV), and mean corpuscu...
The Role of Runx1 N-Terminal Splice Isoforms in Hematopoietic Development
Distal Isoform N-terminus Neutrophil Proximal Runx1
2014/12/10
Runx1/AML1 transcription factor expression in hematopoietic cell lineages is differentially regulated via usage of two distinct promoters. The 5' UTR and a 19 amino acid encoding sequence transcribed ...
Runx1 Regulates c-Myc Expression And The Expansion Of Hematopoietic Precursors In A C-terminally Dependent Manner
Biological sciences Health and environmental sciences C-myc Hematopoiesis Runx1 Tat peptides
2014/12/10
Runx1 regulates the expression of several important target genes and plays critical roles in the process of hematopoiesis. Runx1 by itself is a poor regulator of transcription and instead nucleates tr...