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中国科学院成都生物所研究发现靶向pro-caspase-1治疗炎症的新型候选新药(图)
治疗 细胞 蛋白
2024/9/14
2024年8月19日,中国科学院成都生物研究所生物资源利用中心王飞研究团队联合四川大学化学学院冯小明院士和董顺喜教授团队在药物化学国际顶级期刊Journal of Medicinal Chemistry上发表题为“Discovery of a Covalent Inhibitor of Pro-Caspase-1 Zymogen Blocking NLRP3 Inflammasome Activa...
王雨轩,徐尚,郝芳 等,资源学院 构造与油气资源教育部重点实验室. GSA Bulletin, December 2019. Multiscale petrographic heterogeneity and their implications for the nanoporous system of the Wufeng-Longmaxi shales in Jiaoshiba area, Southeast China: Response to depositional-diagenetic pro
富有机质;页岩;多尺度;非均质;性特征
2021/10/15
近日,资源学院博士生王雨轩在国际著名地质学期刊《GSA Bulletin》上刊发研究成果,研究成果主要揭示了重庆涪陵地区五峰-龙马溪组富有机质页岩的多尺度非均质性特征,探讨了富有机质页岩非均质的成因及其对页岩纳米孔隙体系的影响。
High resolution reflection seismic profiling over the Tjellefonna fault in the Møre-Trøndelag Fault Complex, Norway
refl ection seismic profi ling Tjellefonna fault
2015/1/4
The Møre-Trøndelag Fault Complex (MTFC) is
one of the most prominent fault zones of Norway, both onshore and offshore.
WRFv3.2-SPAv2: development and validation of a coupled ecosystem–atmosphere model, scaling from surface fluxes of CO2 and energy to atmospheric profiles
development ecosystem–atmosphere model
2014/12/12
The Weather Research and Forecasting meteorological (WRF) model has been coupled to the
Soil–Plant–Atmosphere (SPA) terrestrial ecosystem model to produce WRF-SPA.
On pro-$p$ analogues of limit groups via extensions of centralizers
Group Theory extensions of centralizers limit groups pro-$p$ analogues
2011/9/5
Abstract: We begin a study of a pro-$p$ analogue of limit groups via extensions of centralizers and call $\mathcal{L}$ this new class of pro-$p$ groups. We show that the pro-$p$ groups of $\mathcal{L}...
Kernels of Linear Representations of Lie Groups, Locally Compact Groups, and Pro-Lie Groups
Kernels of Linear Representations of Lie Groups Locally Compact Groups Pro-Lie Groups
2011/1/17
For a topological group G the intersection KOR(G) of all kernels of ordinary representations
is studied. We show that KOR(G) is contained in the center of G if G is a connected pro-Lie group.
Green Correspondence for Virtually Pro-p Groups
Green Correspondence Virtually Pro-p Groups
2010/11/22
Let p be prime, k a finite field of characteristic p, and G a virtually pro-p group. We prove an analogue of the Green Correspondence for finitely generated modules over the completed group algebra k[...
稀土脯氨酸配合物[RE2(L-Pro)6(H2O)4](ClO4)6的标准生成焓测定
高氯酸盐 L-脯氨酸 [RE2(L-Pro)6(H2O)4](ClO4)6(RE=Pr,Er) 反应热 标准生成焓
2009/12/7
合成了两种稀土高氯酸盐与L脯氨酸配合物的晶体.经热重、差热、化学分析及对比有关文献,知其组成是[Pr2(LPro)6(H2O)4](ClO4)6和[Er2(LPro)6(H2O)4](ClO4)6,质量分数为99.24%和98.20%.选用RE(NO3)3•6H2O(RE=Pr,Er)、LPro、NaClO4•H2O和NaNO3作辅助物,使用具有恒温环境的反应热量计...
摘要酵母7209一1 A (a) DNA,用pHC79为载体,以BamHI, Pstl和HindIII 酶切,经体外重组和包装后,转导至大肠杆菌HB101和SC294中。在我们的实验条件下(对酵母DNA适度酶解,F/V值为15,连接时DNA总浓度为200-250微克/微升以及BHB 2688/ BHB 2690比值为5),重组建库效率达到106 CFU f微克载体DNA,重组子双抗值降低到10%或...
摘要 Sm(i-Pro)3(2%)/4A分子筛能够有效地催化各类醛、酮的Meerwein-Ponndorf-Verley型还原反应, 反应转化率优良。
[A_(15)Asn,A_(17)Pro,A_(21)Ala]-胰岛素的体内外生物活性
Insulin Insulin analogue Receptor binding Biological activity
2007/12/19
A 15 Asn,A 17 Pro,A 21 Ala] insulin was synthesized by the Fmoc solid phase synthetic method to study the biological significance of the helix in the C terminal region of A chain of insulin.In order t...
摘要 采用L-型脯氨酸(L-Pro)作为原料,三甲基硅烷异硫氰酸酯(TMS-ITC)作为偶联试剂制备脯氨酸乙内酰硫脲(TH-Pro).产物经反相HPLC分离纯化,并通过氨基酸组成分析,紫外光谱扫描,质谱和核磁共振等方法鉴定.反应产率高达96%.
摘要构建了一个含酿酒酵母PRO3基因的分泌型表达载体pCBy310,在pCBy310上插入βHCG(人绒毛膜促性腺激素β亚基)-cDNA以形成一个重组质粒pCBy3 14。利用酿酒酵母脯氨酸合成酶基因缺陷株的独特属性,即它们不能在丰富培基中生长,pCBy314在酿酒酵母Pro3-缺陷株(MB299-A)的转化子可以在丰富培基中生长,而且保持有丝分裂稳定性。在优在条件(但尚非最佳条件)下,βHCG在...