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Genome-wide analysis identifies a role for common copy number variants in specific language impairment
Genome-wide analysis copy number variants specific language impairment
2015/5/13
An exploratory genome-wide copy number variant (CNV) study was performed in 127 independent cases with specific language impairment (SLI), their first-degree relatives (385 individuals) and 269 popula...
Genome wide identification of Fruitless targets suggests a role in upregulating genes important for neural circuit formation
Genome wide identification upregulating genes neural circuit
2015/5/6
The fruitless gene (fru) encodes a set of transcription factors (Fru) that display sexually dimorphic gene expression in the brain of the fruit-fly; Drosophila melanogaster. Behavioural studies have d...
Genome-wide association analyses of child genotype effects and parent-of-origin effects in specific language impairment
ALSPAC GWAS imprinting neurodevelopmental disorder specific language impairment
2015/5/5
Specific language impairment (SLI) is a neurodevelopmental disorder that affects linguistic abilities when development is otherwise normal. We report the results of a genome-wide association study of ...
Genome-wide screening for DNA variants associated with reading and language traits
pleiotropic variants CLDRC developmental dyslexia GWAS language meta-analysis reading reading disability SLIC specific language impairment
2015/5/5
Reading and language abilities are heritable traits that are likely to share some genetic influences with each other. To identify pleiotropic genetic variants affecting these traits, we first performe...
A Genome Wide Association Study of Mathematical Ability Reveals an Association at Chromosome 3q29, a Locus Associated with Autism and Learning Difficulties:A Preliminary Study
Genome Wide Mathematical Ability Chromosome 3q29 Locus Associated with Autism Learning Difficulties
2015/5/5
Mathematical ability is heritable, but few studies have directly investigated its molecular genetic basis. Here we aimed to identify specific genetic contributions to variation in mathematical ability...